Abstract：
Acute myeloid leukemia (AML) has been characterized by the swift development of abnormal cells in the bone marrow. This research aimed to examine the impacts of the miR-185-5p-GPX1 axis on AML progression and differentiation. Findings indicated that miR-185-5p and GPX1 levels were significantly reduced and elevated, respectively. The upregulation of miR-185-5p was observed to restrict the proliferation and invasion abilities of AML cells, and promote differentiate and apoptosis. Moreover, the overexpression of GPX1 was noticed to enhance the growth of AML cells. In conclusion, this research suggested that by targeting GPX1, miR-185-5p inhibited AML progression and downregulated AML cells\' proliferation and invasion.
摘要：
急性髓性白血病（AML）的特征是骨髓中异常细胞的迅速发展。这项研究旨在检查miR-185-5p-GPX1轴对AML进展和分化的影响。结果表明，miR-185-5p和GPX1水平显著降低和升高，分别。观察到miR-185-5p的上调限制AML细胞的增殖和侵袭能力，促进分化和凋亡。此外，GPX1的过表达可促进AML细胞的生长。总之,这项研究表明，通过靶向GPX1，miR-185-5p抑制AML进展和下调AML细胞的增殖和侵袭。
