%0 Journal Article
%T MiR-185-5p suppresses acute myeloid leukemia by inhibiting GPX1.
%A Pang B
%A Mao H
%A Wang J
%A Yang W
%J Microvasc Res
%V 140
%N 0
%D 03 2022 3
%M 34863990
%F 3.75
%R 10.1016/j.mvr.2021.104296
%X Acute myeloid leukemia (AML) has been characterized by the swift development of abnormal cells in the bone marrow. This research aimed to examine the impacts of the miR-185-5p-GPX1 axis on AML progression and differentiation. Findings indicated that miR-185-5p and GPX1 levels were significantly reduced and elevated, respectively. The upregulation of miR-185-5p was observed to restrict the proliferation and invasion abilities of AML cells, and promote differentiate and apoptosis. Moreover, the overexpression of GPX1 was noticed to enhance the growth of AML cells. In conclusion, this research suggested that by targeting GPX1, miR-185-5p inhibited AML progression and downregulated AML cells' proliferation and invasion.