Abstract：
AIDS restriction genes (ARGs) like APOBEC3, TRIM5α, and BST2 can act as immunological detectors of the innate protective mechanism of the body. ARGs influence the course of viral pathogenesis and progression of the disease. The infection caused by different viruses including HIV activates the innate immune receptors leading to production of proinflammatory cytokines, interferons and signals that recruit and activate cells involved in the process of inflammation following induction of adaptive immunity. Differential expression of genes involved in viral infection decide the fate and subsequent susceptibility to infection and its clinical outcome. Nevertheless, comprehensive reports on the incidence of genetic polymorphism of APOBEC3s, TRIM5α, and BST-2 in the general population and its association with pathological conditions have not been described well. Therefore, the occurrence of APOBEC3, TRIM5α, and BST2 polymorphism in healthy individuals and its impact on HIV transmission was analyzed. We conducted an extensive search using the several databases including, EMBASE, PubMed (Medline), and Google Scholar. APOBEC3-D, -F, -G, and -H out of the seven human APOBEC3s, help in the control of viral infection. Amongst various restriction factors, TRIM5α and BST-2 also restrict the viral infection followed by the development of the disease. In the current review, a brief account of the polymorphism in the APOBEC3G, TRIM5α, and BST2 genes are explored among different populations along with the interaction of APOBEC3G with Vif protein. Furthermore, this review specifically focus on ARGs polymorphism (APOBEC3G, TRIM5α, and BST2) associated with HIV transmission.
摘要：
AIDS限制性基因(ARGs)如APOBEC3、TRIM5α、和BST2可以作为机体先天保护机制的免疫学检测器。ARGs影响病毒发病过程和疾病进展。由包括HIV在内的不同病毒引起的感染激活先天免疫受体，导致促炎细胞因子的产生，在诱导适应性免疫后募集和激活参与炎症过程的细胞的干扰素和信号。与病毒感染有关的基因的差异表达决定了感染的命运和随后的易感性及其临床结果。然而，关于APOBEC3基因多态性发病率的综合报道，TRIM5α,一般人群中的BST-2及其与病理状况的关系尚未得到很好的描述。因此,APOBEC3，TRIM5α，分析了健康个体的BST2多态性及其对HIV传播的影响。我们使用几个数据库进行了广泛的搜索，包括，EMBASE,PubMed(Medline),谷歌学者。APOBEC3-D,-F,-G,和-H在七个人类APOBEC3中，帮助控制病毒感染。在各种制约因素中，TRIM5α和BST-2也限制了病毒感染，然后是疾病的发展。在当前的审查中，简要介绍了APOBEC3G中的多态性，TRIM5α,以及APOBEC3G与Vif蛋白的相互作用，在不同人群中探索BST2基因。此外，这篇综述特别关注ARGs多态性(APOBEC3G，TRIM5α,和BST2）与HIV传播有关。
