PDF(Pubmed)
Abstract：
Heart failure with preserved ejection fraction (HFpEF) has been an emerging type of cardiac disease since the pseudo-left ventricle function is preserved; therefore, challenges in finding the target and treatment. Damage and pathogen-associated molecular patterns (DAMPs and PAMPs) are widely investigated in acute and chronic inflammation in heart failure; however, lifestyle-associated molecular patterns (LAMPs: diet, sleep, exercise), particularly in obesity, remains of interest due to the enormous increase of HFpEF patients. In this review, we covered obesity-related cardiomyopathy, LAMPs, and resolution receptor dysfunction in the context of heart failure with preserved ejection fraction.
摘要：
射血分数保留的心力衰竭（HFpEF）已成为一种新兴的心脏病，因为假左心室功能得以保留；因此，寻找目标和治疗方面的挑战。损伤和病原体相关分子模式(DAMPs和PAMPs)在心力衰竭的急性和慢性炎症中被广泛研究；然而，与生活方式相关的分子模式(LAMMPs：饮食，睡眠,锻炼)，特别是在肥胖症中，由于HFpEF患者的大量增加，仍然令人感兴趣。在这次审查中,我们报道了肥胖相关的心肌病,LAMMPs,在射血分数保留的心力衰竭的情况下，解决受体功能障碍。
