PDF(Pubmed)
Abstract：
Calcineurin, also known as protein phosphatase 2B, is a heterodimeric serine threonine phosphatase involved in numerous signaling pathways. During the past 50 years, calcineurin has been the subject of extensive investigation. Many of its cellular and physiological functions have been described, and the underlying biophysical mechanisms are the subject of active investigation. With the abundance of techniques and experimental designs utilized to study calcineurin and its numerous substrates, it is difficult to reconcile the available information. There have been a plethora of reports describing the role of calcineurin in cardiac disease. However, a physiological role of calcineurin in healthy cardiomyocyte function requires clarification. Here, we review the seminal biophysical and structural details that are responsible for the molecular function and inhibition of calcineurin. We then focus on literature describing the roles of calcineurin in cardiomyocyte physiology and disease.
摘要：
钙调磷酸酶,也被称为蛋白磷酸酶2B，是参与许多信号通路的异二聚体丝氨酸苏氨酸磷酸酶。在过去的50年里,钙调磷酸酶一直是广泛研究的主题。它的许多细胞和生理功能已经被描述，潜在的生物物理机制是积极研究的主题。随着用于研究钙调磷酸酶及其众多底物的大量技术和实验设计，很难调和现有信息。已有大量报道描述钙调磷酸酶在心脏病中的作用。然而,钙调磷酸酶在健康心肌细胞功能中的生理作用需要澄清。这里,我们回顾了负责钙调磷酸酶分子功能和抑制的开创性生物物理和结构细节。然后，我们专注于描述钙调磷酸酶在心肌细胞生理和疾病中的作用的文献。
