PDF(Pubmed)
Abstract：
OBJECTIVE: To summarize the evidence on the feasibility of maxillomandibular imaging exams-related fractal dimension (FD) in screening patients with osteoporosis.
METHODS: This registered systematic review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses of Diagnostic Test Accuracy statement. High sensitivity search strategies were developed for six primary databases and grey literature. Quality Assessment of Diagnostic Accuracy Studies (QUADAS-2) items evaluated the risk of bias, and the GRADE approach assessed the evidence certainty.
RESULTS: From 1034 records initially identified through database searching, four studies were included (total sample of 747 patients [osteoporosis, 136; control group, 611]). The meta-analysis showed that the overall sensitivity and specificity of the FD were 86.17 and 72.68%, respectively. In general, all studies showed low RoB and applicability concern. The certainty of the evidence was very low to moderate.
CONCLUSIONS: This systematic review showed that the jaw-related FD presented sensitivity and specificity values higher than 70%, and its sensitivity in osteoporosis screening was a better parameter than specificity.
METHODS: This registered systematic review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses of Diagnostic Test Accuracy statement. High sensitivity search strategies were developed for six primary databases and grey literature. Quality Assessment of Diagnostic Accuracy Studies (QUADAS-2) items evaluated the risk of bias, and the GRADE approach assessed the evidence certainty.
RESULTS: From 1034 records initially identified through database searching, four studies were included (total sample of 747 patients [osteoporosis, 136; control group, 611]). The meta-analysis showed that the overall sensitivity and specificity of the FD were 86.17 and 72.68%, respectively. In general, all studies showed low RoB and applicability concern. The certainty of the evidence was very low to moderate.
CONCLUSIONS: This systematic review showed that the jaw-related FD presented sensitivity and specificity values higher than 70%, and its sensitivity in osteoporosis screening was a better parameter than specificity.
摘要：
目的：总结上颌下颌关节影像学检查相关分形维数(FD)在骨质疏松患者筛查中的可行性。
方法：本注册系统评价遵循诊断测试准确性陈述的系统评价和荟萃分析的首选报告项目。针对六个主要数据库和灰色文献开发了高灵敏度搜索策略。诊断准确性研究的质量评估（QUADAS-2）项目评估了偏倚的风险，等级方法评估了证据的确定性。
结果：从最初通过数据库搜索确定的1034条记录中，纳入了四项研究(总共747名患者[骨质疏松症，136；对照组，611]).Meta分析结果显示,FD的总体敏感性和特异性分别为86.17和72.68%,分别。总的来说,所有研究均显示低RoB和适用性问题。证据的确定性非常低至中等。
结论：这项系统评价显示，颌骨相关FD的敏感性和特异性值高于70％，其在骨质疏松筛查中的敏感性优于特异性。
方法：本注册系统评价遵循诊断测试准确性陈述的系统评价和荟萃分析的首选报告项目。针对六个主要数据库和灰色文献开发了高灵敏度搜索策略。诊断准确性研究的质量评估（QUADAS-2）项目评估了偏倚的风险，等级方法评估了证据的确定性。
结果：从最初通过数据库搜索确定的1034条记录中，纳入了四项研究(总共747名患者[骨质疏松症，136；对照组，611]).Meta分析结果显示,FD的总体敏感性和特异性分别为86.17和72.68%,分别。总的来说,所有研究均显示低RoB和适用性问题。证据的确定性非常低至中等。
结论：这项系统评价显示，颌骨相关FD的敏感性和特异性值高于70％，其在骨质疏松筛查中的敏感性优于特异性。
