Abstract：
Developments of novel drug delivery vehicles are sought-after to augment the therapeutic effectiveness of standard drugs. An urgency to design novel drug delivery vehicles that are sustainable, biocompatible, have minimized cytotoxicity, no immunogenicity, high stability, long circulation time, and are capable of averting recognition by the immune system is perceived. In this pursuit for an ideal candidate for drug delivery vehicles, zwitterionic materials have come up as fulfilling almost all these expectations. This comprehensive review is presenting the progress made by zwitterionic polymeric architectures as prospective sustainable drug delivery vehicles. Zwitterionic polymers with varied architecture such as appending protein conjugates, nanoparticles, surface coatings, liposomes, hydrogels, etc, used to fabricate drug delivery vehicles are reviewed here. A brief introduction of zwitterionic polymers and their application as reliable drug delivery vehicles, such as zwitterionic polymer-protein conjugates, zwitterionic polymer-based drug nanocarriers, and stimulus-responsive zwitterionic polymers are discussed in this discourse. The prospects shown by zwitterionic architecture suggest the tremendous potential for them in this domain. This critical review will encourage the researchers working in this area and boost the development and commercialization of such devices to benefit the healthcare fraternity.
摘要：
寻求新型药物递送载体的开发以增强标准药物的治疗有效性。迫切需要设计可持续的新型药物输送工具，生物相容性具有最小化的细胞毒性，无免疫原性,高稳定性,循环时间长,并且能够避免免疫系统的识别。在这种对理想的候选药物输送车辆的追求，两性离子材料已经实现了几乎所有这些期望。这篇全面的综述介绍了两性离子聚合物结构作为前瞻性可持续药物递送载体所取得的进展。具有不同结构的两性离子聚合物，如附加蛋白质缀合物，纳米粒子，表面涂层,脂质体，水凝胶,etc,本文对用于制造药物输送载体的方法进行了综述。简要介绍了两性离子聚合物及其作为可靠药物递送载体的应用，如两性离子聚合物-蛋白质缀合物，基于两性离子聚合物的药物纳米载体，本文讨论了刺激响应性两性离子聚合物。两性离子结构显示的前景表明了它们在该领域的巨大潜力。这项重要的审查将鼓励在这一领域工作的研究人员，并促进此类设备的开发和商业化，以使医疗保健协会受益。
