基因组的 3D 无序和重排通过整合的 Hi - C , 提供了对 NAFLD 发病机理的见解。纳米孔,和 RNA 测序。
关键词: 3C, chromosome conformation capture 3D genome 3D, three-dimensional ALT, alanine aminotransferase AST, aspartate aminotransferase Abcg5, ATP-binding cassette sub-family G member 5 BWA, Burrows-Wheeler Aligner CNV, copy number variation Camk1d, calcium/calmodulin-dependent protein kinase type 1D Chr, chromosome Chromatin looping DEG, differentially expressed gene DEL, deletion DI, directionality index DUP, duplication Elovl6, elongation of very long chain fatty acids protein 6 FDR, false discovery rate FFA, free fatty acid Fgfr2, fibroblast growth factor receptor 2 GCKR, glucokinase regulator GO, gene ontology GSH, glutathione Gadd45g, growth arrest and DNA damage-inducible protein GADD45 gamma Grm8, metabotropic glutamate receptor 8 Gsta1, glutathione S-transferase A1 H&E, hematoxylin-eosin HFD, high-fat diet HSD17B13, hydroxysteroid 17-beta dehydrogenase 13 Hi-C, high-throughput chromosome conformation capture IDE, interaction decay exponent INS, insertion INV, inversion IR, inclusion ratio IRGM, immunity related GTPase M IRS4, insulin receptor substrate 4 KEGG, Kyoto Encyclopedia of Genes and Genomes Kcnma1, calcium-activated potassium channel subunit alpha-1 LPIN1, lipin 1 MBOAT7, membrane bound O-acyltransferase domain containing 7 MDA, malondialdehyde NAFLD, non-alcoholic fatty liver disease NF1, neurofibromin 1 NGS, next-generation sequencing NOTCH1, notch receptor 1 ONT, Oxford Nanopore Technologies PCA, principal component analysis PNPLA3, patatin like phospholipase domain containing 3 PPP1R3B, protein phosphatase 1 regulatory subunit 3B PTEN, phosphatase and tensin homolog Pde4b, phosphodiesterase 4B Plce1, 1-phosphat-idylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 Plxnb1, Plexin-B1 RB1, RB transcriptional corepressor 1 RNA-seq, RNA-sequencing SD, standard deviation SOD, superoxide dismutase SV, structural variation Scd1, acyl-CoA desaturase 1 Sugct, succinate-hydroxymethylglutarate CoA-transferase TAD, topologically associated domain TC, total cholesterol TG, triglyceride TM6SF2, transmembrane 6 superfamily member 2 TP53, tumor protein p53 TRA, translocation Topologically associated domain Transcriptome WGS, whole-genome sequencing Whole-genome sequencing
来 源:
DOI:10.1016/j.apsb.2021.03.022
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