PDF(Pubmed)
Abstract：
A-type lamins are the main structural components of the nucleus, which are mainly localized at the nucleus periphery. First of all, A-type lamins, together with B-type lamins and proteins of the inner nuclear membrane, form a stiff structure-the nuclear lamina. Besides maintaining the nucleus cell shape, A-type lamins play a critical role in many cellular events, such as gene transcription and epigenetic regulation. Nowadays it is clear that lamins play a very important role in determining cell fate decisions. Various mutations in genes encoding A-type lamins lead to damages of different types of tissues in humans, collectively known as laminopathies, and it is clear that A-type lamins are involved in the regulation of cell differentiation and stemness. However, the mechanisms of this regulation remain unclear. In this review, we discuss how A-type lamins can execute their regulatory role in determining the differentiation status of a cell. We have summarized recent data focused on lamin A/C action mechanisms in regulation of cell differentiation and identity development of stem cells of different origin. We also discuss how this knowledge can promote further research toward a deeper understanding of the role of lamin A/C mutations in laminopathies.
摘要：
A型层是细胞核的主要结构成分,主要位于细胞核外围。首先,A型薄片，连同B-型层合蛋白和内核膜的蛋白质,形成坚硬的结构-核层。除了维持细胞核细胞的形状，A型层蛋白在许多细胞事件中起关键作用，如基因转录和表观遗传调控。如今，很明显，层板在决定细胞命运的决定中起着非常重要的作用。编码A型层粘连蛋白的基因中的各种突变导致人类不同类型组织的损伤,统称为层粘连病，很明显，A型层粘连蛋白参与细胞分化和干性的调节。然而,这一规定的机制尚不清楚.在这次审查中,我们讨论了A型层粘连蛋白如何在确定细胞分化状态中发挥调节作用。我们总结了最近的数据，这些数据集中在不同来源的干细胞的细胞分化和身份发育的调节中的层粘连蛋白A/C作用机制。我们还讨论了这些知识如何促进进一步的研究，以更深入地了解层粘连蛋白A/C突变在层粘连蛋白病中的作用。
