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Abstract：
Colorectal cancer (CRC) is one of the most common carcinomas. Although great progress has been made in recent years, CRC survival remains unsatisfactory due to high metastasis and recurrence. Understanding the underlying molecular mechanisms of CRC tumorigenesis and metastasis has become increasingly important. Recently, aberrant Wnt/β‑catenin signaling has been reported to be strongly associated with CRC tumorigenesis, metastasis and recurrence. Therefore, the Wnt/β‑catenin signaling pathway has potential value as a therapeutic target for CRC. In the present review, the dysregulation of this pathway in CRC and the promoting or suppressing function of therapeutic targets on CRC were explored. In addition, the interaction between this pathway and epithelial‑mesenchymal transition (EMT), cell stemness, mutations, metastasis‑related genes and tumor angiogenesis in CRC cells were also investigated. Numerous studies on this pathway may help identify the potential diagnostic and prognostic markers and therapeutic targets for CRC.
摘要：
结直肠癌（CRC）是最常见的癌症之一。尽管近年来取得了很大进展，由于高转移和复发，CRC的生存率仍然不令人满意。了解CRC肿瘤发生和转移的潜在分子机制变得越来越重要。最近,据报道，异常的Wnt/β‑catenin信号与CRC肿瘤发生密切相关，转移和复发。因此,Wnt/β‑catenin信号通路作为CRC治疗靶点具有潜在价值。在本次审查中，探讨了该通路在CRC中的失调以及对CRC治疗靶点的促进或抑制功能。此外,该途径与上皮间质转化（EMT）之间的相互作用，细胞干细胞，突变,还研究了CRC细胞中与转移相关的基因和肿瘤血管生成。对该途径的大量研究可能有助于确定CRC的潜在诊断和预后标志物和治疗靶标。
