Abstract：
OBJECTIVE: To quantify otolaryngologic surgery utilization in patients with achondroplasia, and to identify any changes in utilization over the past four decades.
METHODS: Retrospective cohort study.
METHODS: A retrospective cohort study of 1,374 patients with achondroplasia enrolled in the CLARITY retrospective cohort study at four centers of multi-specialty care for patients with achondroplasia. Otolaryngologic surgeries are presented by birth cohort decade. The main outcomes were number of primary and additional otolaryngologic procedures; age at surgery; likelihood of repeated surgery; temporal trends in surgical utilization.
RESULTS: In this cohort of 1,374 patients with achondroplasia, 620 (45.1%) had pharyngeal surgery at least once, 150 (10.9%) had pharyngeal surgery on more than one occasion, and patients who had adenoidectomy first were 2.68 times more likely to require a second pharyngeal surgery than those who had adenotonsillectomy. Seven hundred and seventy-nine (56.7%) had tympanostomy tubes placed at least once, and 447 (32.5%) had tympanostomy tubes placed more than one time. Age at first pharyngeal surgery decreased by 1.2 years per birth cohort decade, and age at tympanostomy tube placement decreased by 1.1 years per decade.
CONCLUSIONS: Patients with achondroplasia often require otolaryngologic surgery, particularly adenoidectomy and/or tonsillectomy as well as tympanostomy tube placement. Such surgery is performed now more frequently and at younger ages than in earlier decades. While otolaryngologic disease associated with achondroplasia is now recognized earlier and treated more frequently, long-term outcome studies are needed.
METHODS: 3 Laryngoscope, 2021.
METHODS: Retrospective cohort study.
METHODS: A retrospective cohort study of 1,374 patients with achondroplasia enrolled in the CLARITY retrospective cohort study at four centers of multi-specialty care for patients with achondroplasia. Otolaryngologic surgeries are presented by birth cohort decade. The main outcomes were number of primary and additional otolaryngologic procedures; age at surgery; likelihood of repeated surgery; temporal trends in surgical utilization.
RESULTS: In this cohort of 1,374 patients with achondroplasia, 620 (45.1%) had pharyngeal surgery at least once, 150 (10.9%) had pharyngeal surgery on more than one occasion, and patients who had adenoidectomy first were 2.68 times more likely to require a second pharyngeal surgery than those who had adenotonsillectomy. Seven hundred and seventy-nine (56.7%) had tympanostomy tubes placed at least once, and 447 (32.5%) had tympanostomy tubes placed more than one time. Age at first pharyngeal surgery decreased by 1.2 years per birth cohort decade, and age at tympanostomy tube placement decreased by 1.1 years per decade.
CONCLUSIONS: Patients with achondroplasia often require otolaryngologic surgery, particularly adenoidectomy and/or tonsillectomy as well as tympanostomy tube placement. Such surgery is performed now more frequently and at younger ages than in earlier decades. While otolaryngologic disease associated with achondroplasia is now recognized earlier and treated more frequently, long-term outcome studies are needed.
METHODS: 3 Laryngoscope, 2021.
摘要：
目的：量化软骨发育不全患者的耳鼻喉手术利用率，并确定过去四十年来利用率的任何变化。
方法：回顾性队列研究。
方法：一项纳入CLARITY回顾性队列研究的1,374例软骨发育不全患者的回顾性队列研究，该研究在4个多专业治疗中心进行。耳鼻咽喉手术按出生队列十年进行。主要结果是初次和额外的耳鼻喉手术的数量；手术年龄；重复手术的可能性；手术利用率的时间趋势。
结果：在1,374例软骨发育不全患者的队列中，620（45.1％）进行了至少一次咽部手术，150人（10.9％）多次进行了咽部手术，首先进行腺样体切除术的患者需要进行第二次咽部手术的可能性是进行腺样体扁桃体切除术的患者的2.68倍。七百七十九（56.7％）至少放置了一次鼓膜造口管，447（32.5％）的鼓膜置管超过一次。首次咽部手术的年龄每出生队列十年减少1.2岁，鼓膜置管时的年龄每十年减少1.1年。
结论：软骨发育不全患者通常需要耳鼻喉手术，特别是腺样体切除术和/或扁桃体切除术以及鼓膜置管放置。与前几十年相比，现在进行这种手术的频率更高，年龄更小。虽然与软骨发育不全相关的耳鼻喉疾病现在被更早地认识到并且更频繁地治疗，需要进行长期结果研究.
方法：3喉镜，2021年。
方法：回顾性队列研究。
方法：一项纳入CLARITY回顾性队列研究的1,374例软骨发育不全患者的回顾性队列研究，该研究在4个多专业治疗中心进行。耳鼻咽喉手术按出生队列十年进行。主要结果是初次和额外的耳鼻喉手术的数量；手术年龄；重复手术的可能性；手术利用率的时间趋势。
结果：在1,374例软骨发育不全患者的队列中，620（45.1％）进行了至少一次咽部手术，150人（10.9％）多次进行了咽部手术，首先进行腺样体切除术的患者需要进行第二次咽部手术的可能性是进行腺样体扁桃体切除术的患者的2.68倍。七百七十九（56.7％）至少放置了一次鼓膜造口管，447（32.5％）的鼓膜置管超过一次。首次咽部手术的年龄每出生队列十年减少1.2岁，鼓膜置管时的年龄每十年减少1.1年。
结论：软骨发育不全患者通常需要耳鼻喉手术，特别是腺样体切除术和/或扁桃体切除术以及鼓膜置管放置。与前几十年相比，现在进行这种手术的频率更高，年龄更小。虽然与软骨发育不全相关的耳鼻喉疾病现在被更早地认识到并且更频繁地治疗，需要进行长期结果研究.
方法：3喉镜，2021年。
