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Abstract：
OBJECTIVE: To study the influence of media opacity due to cataract on the development of axial length in paediatric patients from North-East India, using optical biometry.
METHODS: This is a prospective, observational study, including consecutive patients attending the paediatric ophthalmology clinic, over a period of 1 year. Patients with other ocular and systemic diseases, unfit for optical biometry measurements due to dense cataract, nystagmus and strabismus were excluded and rest divided into three groups after proper age matching - 1. Group A (Bilateral cataract) 2. Group B (Unilateral cataract) 3. Group C (Bilateral normal). The axial length of the various groups was analysed using independent sample test (for bilateral cataract group) and paired t-test (for unilateral cataract group). Linear regression analysis between age and axial length was done.
RESULTS: A total of 177 patients were included.80 cases in Group A (bilateral cataract), 18 cases in Group B (unilateral cataract) and 79 in Group C (bilateral normal) The mean age of the patients in all the groups was 8.88 ± 3.51 years (range: 1-17 years). The bivariate analysis and simple linear regression revealed a statistically significant correlation between age and AL in case of cataractous eyes. (Pearson\'s coefficient: 0.341, p < 0.001). The mean AL was significantly longer (p = 0.013) in the cataractous eyes (mean = 23.38 ± 2.08 mm) of Group A(bilateral cataract) in the 7-12 years age group as compared to the bilaterally normal eyes (mean AL = 22.57 ± 0.70 mm) of patients in the same age group in Group C. The mean AL of cataractous eyes in group B (unilateral cataract) (mean = 22.46 ± 1.73 mm) as compared to the fellow normal eyes, (mean = 21.87 ± 0.97 mm) was not statistically significant.
CONCLUSIONS: Cataractous eyes have an abnormal axial length development. The influence of media opacity due to cataract on development of axial length in paediatric eyes in the North-East Indian population is variable, in line with global data on the same. Although there is some influence of media opacity, the exact nature is not clearly understood and may have a crucial interaction with genetic and other environmental factors. Genetic testing integrated with biometric analysis is recommended for further understanding of the ocular growth and development.
METHODS: This is a prospective, observational study, including consecutive patients attending the paediatric ophthalmology clinic, over a period of 1 year. Patients with other ocular and systemic diseases, unfit for optical biometry measurements due to dense cataract, nystagmus and strabismus were excluded and rest divided into three groups after proper age matching - 1. Group A (Bilateral cataract) 2. Group B (Unilateral cataract) 3. Group C (Bilateral normal). The axial length of the various groups was analysed using independent sample test (for bilateral cataract group) and paired t-test (for unilateral cataract group). Linear regression analysis between age and axial length was done.
RESULTS: A total of 177 patients were included.80 cases in Group A (bilateral cataract), 18 cases in Group B (unilateral cataract) and 79 in Group C (bilateral normal) The mean age of the patients in all the groups was 8.88 ± 3.51 years (range: 1-17 years). The bivariate analysis and simple linear regression revealed a statistically significant correlation between age and AL in case of cataractous eyes. (Pearson\'s coefficient: 0.341, p < 0.001). The mean AL was significantly longer (p = 0.013) in the cataractous eyes (mean = 23.38 ± 2.08 mm) of Group A(bilateral cataract) in the 7-12 years age group as compared to the bilaterally normal eyes (mean AL = 22.57 ± 0.70 mm) of patients in the same age group in Group C. The mean AL of cataractous eyes in group B (unilateral cataract) (mean = 22.46 ± 1.73 mm) as compared to the fellow normal eyes, (mean = 21.87 ± 0.97 mm) was not statistically significant.
CONCLUSIONS: Cataractous eyes have an abnormal axial length development. The influence of media opacity due to cataract on development of axial length in paediatric eyes in the North-East Indian population is variable, in line with global data on the same. Although there is some influence of media opacity, the exact nature is not clearly understood and may have a crucial interaction with genetic and other environmental factors. Genetic testing integrated with biometric analysis is recommended for further understanding of the ocular growth and development.
摘要：
目的：研究由于白内障引起的介质混浊对印度东北部儿科患者轴向长度发展的影响，使用光学生物测量。
方法：这是一个前瞻性的，观察性研究，包括连续参加儿科眼科诊所的患者，为期1年。患有其他眼部和全身性疾病的患者，由于致密性白内障，不适合光学生物测量，排除眼球震颤和斜视，适当年龄匹配后分为三组-1。A组(双侧白内障)2。B组(单侧白内障)3.C组（双侧正常）。使用独立样本测试（双侧白内障组）和配对t检验（单侧白内障组）分析各组的轴向长度。进行年龄与眼轴长度之间的线性回归分析。
结果：共纳入177例患者。A组（双侧白内障）80例，B组（单侧白内障）18例，C组（双侧正常）79例。所有组患者的平均年龄为8.88±3.51岁（范围：1-17岁）。双变量分析和简单线性回归显示，在白内障眼的情况下，年龄与AL之间存在统计学上的显着相关性。(皮尔逊系数：0.341，p<0.001)。7-12岁年龄组A组（双侧白内障）白内障眼（平均=23.38±2.08mm）的平均AL明显长于C组相同年龄组患者的双侧正常眼（平均AL=22.57±0.70mm）。B组（单侧白内障）白内障眼的平均AL（平均=22.46±1.73mm）（平均值=21.87±0.97mm）无统计学意义。
结论：白内障眼轴长发育异常。在印度东北部人群中，由于白内障引起的介质混浊对儿科眼睛轴长发育的影响是可变的，与全球数据一致。尽管媒体不透明有一些影响，确切的性质尚不清楚，可能与遗传和其他环境因素有重要的相互作用。建议将遗传测试与生物特征分析相结合，以进一步了解眼部的生长和发育。
方法：这是一个前瞻性的，观察性研究，包括连续参加儿科眼科诊所的患者，为期1年。患有其他眼部和全身性疾病的患者，由于致密性白内障，不适合光学生物测量，排除眼球震颤和斜视，适当年龄匹配后分为三组-1。A组(双侧白内障)2。B组(单侧白内障)3.C组（双侧正常）。使用独立样本测试（双侧白内障组）和配对t检验（单侧白内障组）分析各组的轴向长度。进行年龄与眼轴长度之间的线性回归分析。
结果：共纳入177例患者。A组（双侧白内障）80例，B组（单侧白内障）18例，C组（双侧正常）79例。所有组患者的平均年龄为8.88±3.51岁（范围：1-17岁）。双变量分析和简单线性回归显示，在白内障眼的情况下，年龄与AL之间存在统计学上的显着相关性。(皮尔逊系数：0.341，p<0.001)。7-12岁年龄组A组（双侧白内障）白内障眼（平均=23.38±2.08mm）的平均AL明显长于C组相同年龄组患者的双侧正常眼（平均AL=22.57±0.70mm）。B组（单侧白内障）白内障眼的平均AL（平均=22.46±1.73mm）（平均值=21.87±0.97mm）无统计学意义。
结论：白内障眼轴长发育异常。在印度东北部人群中，由于白内障引起的介质混浊对儿科眼睛轴长发育的影响是可变的，与全球数据一致。尽管媒体不透明有一些影响，确切的性质尚不清楚，可能与遗传和其他环境因素有重要的相互作用。建议将遗传测试与生物特征分析相结合，以进一步了解眼部的生长和发育。
