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Abstract：
Cognitive dysfunction syndrome (CDS) is an established condition in cats that shares many similarities with human Alzheimer\'s disease (AD), where cognitive decline ultimately results in dementia. Cats with CDS display behavioural abnormalities, including excessive Vocalisation, altered Interaction with owners (increased affection/attention), altered Sleep-wake cycles, House-soiling, Disorientation (spatial and/or temporal), alterations in Activity, Anxiety, and/or Learning/memory deficits (i.e., VISHDAAL). These cats develop neuropathologies, such as accumulation of β-amyloid and hyperphosphorylated tau deposits. Because of its similarities to those in the brains of people with cognitive impairment and AD, the domestic cat could be a natural model for human dementia studies. It is important to diagnose CDS promptly in cats, ruling out other causes for these behavioural changes, to provide effective management. Interventions include environmental enrichment (e.g., easy access to key resources, calming pheromones), dietary supplementations (e.g., Senilife, Aktivait for cats, SAMe), specific diets (e.g., containing antioxidants, medium-chain triglycerides) and, potentially, medication (e.g., selegiline or propentofylline). This article reviews the literature about CDS in cats, its causes, neuropathology, clinical signs, diagnosis and potential management options. By doing so, it furthers our understanding of this condition and allows improved health, welfare and quality of life of affected cats.
摘要：
认知功能障碍综合征（CDS）是猫的一种既定病症，与人类阿尔茨海默病（AD）有许多相似之处，认知能力下降最终导致痴呆症。带有CDS的猫表现出行为异常，包括过度的发声，改变与业主的互动(增加感情/注意力)，改变睡眠-觉醒周期，房子弄脏，迷失方向（空间和/或时间），活动中的变化，焦虑,和/或学习/记忆缺陷(即，VISHDAAL).这些猫发展成神经病,例如β-淀粉样蛋白和过度磷酸化的tau沉积物的积累。由于它与认知障碍和AD患者的大脑相似，家猫可能是人类痴呆症研究的自然模型。及时诊断猫的CDS非常重要，排除这些行为改变的其他原因，提供有效的管理。干预措施包括环境富集(例如，轻松访问关键资源，镇静信息素)，膳食补充剂(例如，Senilife,Aktivait的猫，SAMe),特定饮食(例如，含有抗氧化剂，中链甘油三酯)和，潜在的,药物(例如，司来吉兰或propentofylline)。本文回顾了有关猫CDS的文献，其原因,神经病理学，临床体征,诊断和潜在的管理选择。通过这样做,它加深了我们对这种情况的理解，并改善了健康，受影响猫的福利和生活质量。
