OBJECTIVE: The aim of this study was to examine CYP1B1 expression in cervical cancers and to assess the enzyme\'s relationship with several clinicopathological features.
METHODS: Immunohistochemistry was performed to examine CYP1B1 expression in 100 patient samples with cervical cancer and 10 patient samples with normal healthy cervical tissues.
RESULTS: CYP1B1 was expressed in the majority of the cervical cancer samples (91/100, 91.0%) but not in normal healthy cervical samples. The difference in the expression of CYP1B1 between healthy and tumorous cervical tissues was significant (P=.01). Moreover, the frequency of CYP1B1 expression was found to be significantly higher in patients with advanced grades of the disease (P=.03) and in patients having metastasis to the lymph nodes (P=.01). Surprisingly, there was a significantly higher expression of CYP1B1 in patients with a high prevalence of human papilloma virus 16/18 (P=.04).
CONCLUSIONS: The differential profile of CYP1B1 expression between cervical cancer tissues and normal cervical tissues suggests that CYP1B1 may be used as a target for future therapeutic exploitations.
目的:本研究的目的是检测CYP1B1在宫颈癌中的表达,并评估该酶与几种临床病理特征的关系。
方法:采用免疫组织化学方法检测100例宫颈癌患者样本和10例正常健康宫颈组织样本中CYP1B1的表达。
结果:CYP1B1在大多数宫颈癌样本中表达(91/100,91.0%),但在正常健康宫颈样本中不表达。CYP1B1在健康和肿瘤宫颈组织中的表达差异有统计学意义(P=0.01)。此外,发现CYP1B1表达频率在疾病晚期患者(P=.03)和淋巴结转移患者(P=.01)中显著较高.令人惊讶的是,CYP1B1在人乳头瘤病毒16/18高患病率患者中的表达明显更高(P=.04).
结论:CYP1B1在宫颈癌组织和正常宫颈组织之间的表达差异表明CYP1B1可能作为未来治疗开发的靶点。