PDF(Pubmed)
Abstract：
There is increasing evidence that lung-resident memory T and B cells play a critical role in protecting against respiratory reinfection. With a unique transcriptional and phenotypic profile, resident memory lymphocytes are maintained in a quiescent state, constantly surveying the lung for microbial intruders. Upon reactivation with cognate antigen, these cells provide rapid effector function to enhance immunity and prevent infection. Immunization strategies designed to induce their formation, alongside novel techniques enabling their detection, have the potential to accelerate and transform vaccine development. Despite most data originating from murine studies, this review will discuss recent insights into the generation, maintenance and characterisation of pulmonary resident memory lymphocytes in the context of respiratory infection and vaccination using recent findings from human and non-human primate studies.
摘要：
越来越多的证据表明，肺部记忆T和B细胞在预防呼吸道再感染中起着关键作用。具有独特的转录和表型特征，常驻记忆淋巴细胞维持在静止状态，不断调查肺部是否有微生物入侵者。用同源抗原重新激活后，这些细胞提供快速的效应子功能，以增强免疫力和防止感染。旨在诱导其形成的免疫策略，除了能够检测到它们的新技术之外，有可能加速和改变疫苗的开发。尽管大多数数据来自鼠类研究，这篇评论将讨论对这一代人的最新见解，使用人类和非人灵长类动物研究的最新发现，在呼吸道感染和疫苗接种的背景下维持和表征肺部常驻记忆淋巴细胞。
