METHODS: A case-control study was carried out to compare the clinical course and outcome of pregnancy in 79 pregnant women with Covid-19 and 85 non-pregnant women with Covid-19 admitted to Latifa Hospital in Dubai between March and June 2020.
RESULTS: Although Pregnant women presented with fewer symptoms such as fever, cough, sore throat, and shortness of breath compared to non-pregnant women; yet they ran a much more severe course of illness. On admission, 12/79 (15.2%) Vs 2/85 (2.4%) had a chest radiograph score [on a scale 1-6] of ≥3 (p-value = 0.0039). On discharge, 6/79 (7.6%) Vs 1/85 (1.2%) had a score ≥3 (p-value = 0.0438). They also had much higher levels of laboratory indicators of severity with values above reference ranges for C-Reactive Protein [(28 (38.3%) Vs 13 (17.6%)] with p < 0.004; and for D-dimer [32 (50.8%) Vs 3(6%)]; with p < 0.001. They required more ICU admissions: 10/79 (12.6%) Vs 1/85 (1.2%) with p=0.0036; and suffered more complications: 9/79 (11.4%) Vs 1/85 (1.2%) with p=0.0066; of Covid-19 infection, particularly in late pregnancy.
CONCLUSIONS: Pregnant women presented with fewer Covid-19 symptoms but ran a much more severe course of illness compared to non-pregnant women with the disease. They had worse chest radiograph scores and much higher levels of laboratory indicators of disease severity. They had more ICU admissions and suffered more complications of Covid-19 infection, such as risk for miscarriage and preterm deliveries. Pregnancy with Covid-19 infection, could, therefore, be categorised as high-risk pregnancy and requires management by an obstetric and medical multidisciplinary team.
方法:进行了一项病例对照研究,比较了2020年3月至6月在迪拜Latifa医院住院的79名Covid-19孕妇和85名非Covid-19孕妇的临床病程和妊娠结局。
结果:虽然孕妇出现发热等症状较少,咳嗽,喉咙痛,与未怀孕的妇女相比,呼吸急促;然而,他们的病情要严重得多。一入场,12/79(15.2%)vs2/85(2.4%)的胸片评分[在1-6量表上]≥3(p值=0.0039)。出院时,6/79(7.6%)vs1/85(1.2%)得分≥3(p值=0.0438)。他们还具有更高水平的实验室严重性指标,其中C反应蛋白的值高于参考范围[(28(38.3%)vs13(17.6%)],p<0.004;D-二聚体[32(50.8%)vs3(6%)];p<0.001。他们需要更多的ICU入院:10/79(12.6%)vs1/85(1.2%),p=0.0036;并且遭受更多的并发症:9/79(11.4%)vs1/85(1.2%),p=0.0066;Covid-19感染,特别是在怀孕后期。
结论:与未怀孕的女性相比,孕妇的新冠肺炎症状较少,但病程要严重得多。他们的胸部X光片评分更差,疾病严重程度的实验室指标水平更高。他们住了更多的ICU,并遭受了更多的新冠肺炎感染并发症,如流产和早产的风险。妊娠合并Covid-19感染,可以,因此,被归类为高危妊娠,需要由产科和医学多学科团队管理。