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Abstract：
Objective: Childhood epilepsy with centrotemporal spikes (CECTS), the most common childhood epilepsy, still lacks longitudinal imaging studies involving antiepileptic drugs (AEDs). In order to examine the effect of AEDs on cognition and brain activity. We investigated the neuromagnetic activities and cognitive profile in children with CECTS before and after 1 year of treatment. Methods: Fifteen children with CECTS aged 6-12 years underwent high-sampling magnetoencephalography (MEG) recordings before treatment and at 1 year after treatment, and 12 completed the cognitive assessment (The Wechsler Intelligence Scale for Children). Next, magnetic source location and functional connectivity (FC) were investigated in order to characterize interictal neuromagnetic activity in the seven frequency sub-bands, including: delta (1-4 Hz), theta (4-8 Hz), alpha (8-12 Hz), beta (12-30 Hz), gamma (30-80 Hz), ripple (80-250 Hz), and fast ripple (250-500 Hz). Results: After 1 year of treatment, children with CECTS had increased scores on full-scale intelligence quotient, verbal comprehension index (VCI) and perceptual reasoning index (PRI). Alterations of neural activity occurred in specific frequency bands. Source location, in the 30-80 Hz frequency band, was significantly increased in the posterior cingulate cortex (PCC) after treatment. Moreover, FC analysis demonstrated that after treatment, the connectivity between the PCC and the medial frontal cortex (MFC) was enhanced in the 8-12 Hz frequency band. Additionally, the whole-brain network distribution was more dispersed in the 80-250 Hz frequency band. Conclusion: Intrinsic neural activity has frequency-dependent characteristic. AEDs have impact on regional activity and FC of the default mode network (DMN). Normalization of aberrant DMN in children with CECTS after treatment is likely the reason for improvement of cognitive function.
摘要：
目标：儿童癫痫伴中央颞部棘波（CECTS），最常见的儿童癫痫，仍然缺乏涉及抗癫痫药物（AEDs）的纵向影像学研究。为了检查AED对认知和大脑活动的影响。我们调查了CECTS患儿治疗前后1年的神经磁活动和认知特征。方法：15例6-12岁的CECTS患儿在治疗前和治疗后1年行高采样脑磁图（MEG）记录，12人完成了认知评估(韦克斯勒儿童智力量表)。接下来,研究了磁源位置和功能连通性（FC），以表征七个频率子带中的发作间神经磁活动，包括：delta（1-4Hz），θ(4-8Hz),阿尔法（8-12赫兹），β（12-30Hz），gamma(30-80Hz),纹波（80-250Hz），和快速纹波（250-500赫兹）。结果：经过1年的治疗，患有CECTS的儿童在全面智商方面得分增加，言语理解指数(VCI)和感知推理指数(PRI)。神经活动的改变发生在特定的频带中。源位置,在30-80Hz频段，治疗后扣带回皮质（PCC）明显增加。此外，FC分析表明，治疗后，PCC和内侧额叶皮质(MFC)之间的连通性在8-12Hz频段得到增强.此外,全脑网络分布在80-250Hz频段更为分散。结论:内在神经活动具有频率依赖性。AED对区域活动和默认模式网络(DMN)的FC有影响。CECTS患儿治疗后异常DMN的正常化可能是认知功能改善的原因。
