Abstract：
UNASSIGNED: The purpose of this study was to evaluate the early alterations of left ventricular (LV) structure and function in type 2 diabetes mellitus (T2DM) patients with or without obstructive sleep apnoea (OSA) using 3 D speckle tracking echocardiography (3DSTE).
UNASSIGNED: Eighty T2DM patients with preserved LVEF were included, half of whom had OSA as co-morbidity. Forty age- and sex-matched controls were also enrolled. LV structure and function were evaluated by conventional echocardiography and 3DSTE. LV global longitudinal strain (GLS), global circumferential strain (GCS), global area strain (GAS), and global radial strain (GRS) were all measured by 3DSTE.
UNASSIGNED: Four geometric patterns (normal geometry, concentric remodelling, concentric and eccentric hypertrophy) occupied significantly different proportions within the three groups (p = .014). LV remodelling made up higher shares in two T2DM groups than in the controls, whereas LV hypertrophy appeared most frequently in the patients with T2DM and OSA. The patients with T2DM alone had significantly lower GLS and GCS than the controls (both p < .01). The patients with T2DM and OSA had significantly lower GLS, GCS, GAS, and GRS than the controls and the patients with T2DM alone (all p < .01). Fasting plasma glucose (FPG), OSA and BMI had negative impacts on all and part of the strain values in T2DM patients. The T2DM patients with moderate-to-severe OSA showed significantly lower GLS, GCS, GAS, and GRS than those with mild OSA (all p < .05).
UNASSIGNED: The 3DSTE plus conventional echocardiography could detect the sub-clinical LV alterations in T2DM patients with or without OSA.
UNASSIGNED: Eighty T2DM patients with preserved LVEF were included, half of whom had OSA as co-morbidity. Forty age- and sex-matched controls were also enrolled. LV structure and function were evaluated by conventional echocardiography and 3DSTE. LV global longitudinal strain (GLS), global circumferential strain (GCS), global area strain (GAS), and global radial strain (GRS) were all measured by 3DSTE.
UNASSIGNED: Four geometric patterns (normal geometry, concentric remodelling, concentric and eccentric hypertrophy) occupied significantly different proportions within the three groups (p = .014). LV remodelling made up higher shares in two T2DM groups than in the controls, whereas LV hypertrophy appeared most frequently in the patients with T2DM and OSA. The patients with T2DM alone had significantly lower GLS and GCS than the controls (both p < .01). The patients with T2DM and OSA had significantly lower GLS, GCS, GAS, and GRS than the controls and the patients with T2DM alone (all p < .01). Fasting plasma glucose (FPG), OSA and BMI had negative impacts on all and part of the strain values in T2DM patients. The T2DM patients with moderate-to-severe OSA showed significantly lower GLS, GCS, GAS, and GRS than those with mild OSA (all p < .05).
UNASSIGNED: The 3DSTE plus conventional echocardiography could detect the sub-clinical LV alterations in T2DM patients with or without OSA.
摘要：
UNASSIGNED：本研究的目的是使用3D斑点追踪超声心动图（3DSTE）评估有或没有阻塞性睡眠呼吸暂停（OSA）的2型糖尿病（T2DM）患者左心室（LV）结构和功能的早期改变。
未经证实：纳入80例LVEF保留的T2DM患者，其中一半患有OSA合并症。40个年龄和性别匹配的对照也被纳入。通过常规超声心动图和3DSTE评估LV的结构和功能。低压全球纵向应变(GLS),全局周向应变(GCS)，全球区域应变(GAS)，和整体径向应变（GRS）均通过3DSTE测量。
未经评估：四种几何图案（正常几何，同心重塑，同心和偏心肥大）在三组中占据显着不同的比例（p=.014）。LV重构在两个T2DM组中的份额高于对照组，而左心室肥厚在T2DM和OSA患者中最常见。单独的T2DM患者的GLS和GCS明显低于对照组（p均<0.01）。T2DM和OSA患者GLS显著降低，GCS,GAS,GRS高于对照组和单纯T2DM患者(均p<0.01)。空腹血糖(FPG),OSA和BMI对T2DM患者的全部和部分应变值有负面影响。合并中重度OSA的T2DM患者GLS显著降低,GCS,GAS,GRS高于轻度OSA患者（均p<0.05）。
未经证实：3DSTE加常规超声心动图可以检测有或没有OSA的T2DM患者的亚临床LV改变。
未经证实：纳入80例LVEF保留的T2DM患者，其中一半患有OSA合并症。40个年龄和性别匹配的对照也被纳入。通过常规超声心动图和3DSTE评估LV的结构和功能。低压全球纵向应变(GLS),全局周向应变(GCS)，全球区域应变(GAS)，和整体径向应变（GRS）均通过3DSTE测量。
未经评估：四种几何图案（正常几何，同心重塑，同心和偏心肥大）在三组中占据显着不同的比例（p=.014）。LV重构在两个T2DM组中的份额高于对照组，而左心室肥厚在T2DM和OSA患者中最常见。单独的T2DM患者的GLS和GCS明显低于对照组（p均<0.01）。T2DM和OSA患者GLS显著降低，GCS,GAS,GRS高于对照组和单纯T2DM患者(均p<0.01)。空腹血糖(FPG),OSA和BMI对T2DM患者的全部和部分应变值有负面影响。合并中重度OSA的T2DM患者GLS显著降低,GCS,GAS,GRS高于轻度OSA患者（均p<0.05）。
未经证实：3DSTE加常规超声心动图可以检测有或没有OSA的T2DM患者的亚临床LV改变。
