PDF(Pubmed)
Abstract：
Cross-replicating associations with rs657152 at the 9q34.2c locus and rs11385942 at the 3p21.31 locus found in patients with severe COVID-19 in the Caucasian population require the study of the discovered phenomenon in various populations, including as an independent biological marker. Primers and TaqMan probes for PCR discrimination of the A and C alleles in single nucleotide polymorphism (SNP) rs657152 have been developed. The polymorphism of the rs657152 A/C locus was determined in 129 patients with COVID-19 and in a control group of 466 healthy individuals. There were no significant differences in the frequency of distribution of the A and C alleles, 0.47/0.53 and 0.45/0.55, between patients and healthy subjects, respectively. Also, no differences were found in the distribution of alleles in patients with a high viral load in the smear (Ct in the range of 16-25) in comparison with an average and low viral load (Ct in the range of 26-40).
摘要：
在高加索人群中，在重度COVID-19患者中发现的9q34.2c位点的rs657152和3p21.31位点的rs11385942的交叉复制关联需要对各种人群中发现的现象进行研究，包括作为一个独立的生物标记。已经开发了用于PCR区分单核苷酸多态性（SNP）rs657152中A和C等位基因的引物和TaqMan探针。在129名COVID-19患者和466名健康个体的对照组中确定了rs657152A/C基因座的多态性。A和C等位基因的分布频率没有显著差异，0.47/0.53和0.45/0.55，患者和健康受试者之间，分别。此外，涂片中病毒载量高(Ct范围为16~25)患者的等位基因分布与平均病毒载量低(Ct范围为26~40)患者的等位基因分布无差异.
