脑性状相关变异在神经发生过程中影响细胞类型特异性基因调节。
关键词: cell-type specificity common genetic variants expression/splicing quantitative loci genome-wide association study neurogenesis neuropsychiatric disorders transcriptome-wide association study
Mesh : Alleles Alzheimer Disease / diagnosis genetics metabolism Cell Differentiation Chromatin / chemistry metabolism Chromosomal Proteins, Non-Histone / genetics metabolism Chromosome Mapping Educational Status Female Fetus Gene Expression Regulation, Developmental Genetic Predisposition to Disease Genome, Human Genome-Wide Association Study Humans Male Neocortex / cytology growth & development metabolism Neural Stem Cells / cytology metabolism Neurogenesis / genetics Neurons / cytology metabolism Neuroticism Parkinson Disease / diagnosis genetics metabolism Primary Cell Culture Prognosis Quantitative Trait Loci Schizophrenia / diagnosis genetics metabolism Transcriptome
来 源:
DOI:10.1016/j.ajhg.2021.07.011
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