PDF(Pubmed)
Abstract：
UNASSIGNED: Hidradenitis suppurativa (HS) and atopic dermatitis (AD) are both chronic inflammatory skin diseases. An association between these 2 conditions can have important potential implications for elucidating pathogenesis, disease course, and treatment.
UNASSIGNED: To investigate the association between AD and HS.
UNASSIGNED: We performed a retrospective cohort study of patients seen at Duke University Medical Center from 2007 to 2017 who had AD compared with a control group without an AD diagnosis. The association of AD and HS was evaluated using a logistic regression model after adjusting for other confounders including age, sex, and race.
UNASSIGNED: Of 28,780 patients with an AD diagnosis, 325 (1.1%) were diagnosed with HS compared with 76 (0.2%) within the 48,383 patients in the non-AD group. An adjusted logistic regression model demonstrated an increased odds ratio of having HS diagnosis in the AD group as compared with the control non-AD group (odds ratio: 5.57, 95% confidence interval: 4.30-7.21, P < .001).
UNASSIGNED: This was a retrospective study performed at a single institution with the possibility of surveillance bias being present.
UNASSIGNED: Patients with AD are more likely to be diagnosed with HS than patients without AD. Further research is needed to understand the pathophysiologic mechanism and potential treatment implications.
UNASSIGNED: To investigate the association between AD and HS.
UNASSIGNED: We performed a retrospective cohort study of patients seen at Duke University Medical Center from 2007 to 2017 who had AD compared with a control group without an AD diagnosis. The association of AD and HS was evaluated using a logistic regression model after adjusting for other confounders including age, sex, and race.
UNASSIGNED: Of 28,780 patients with an AD diagnosis, 325 (1.1%) were diagnosed with HS compared with 76 (0.2%) within the 48,383 patients in the non-AD group. An adjusted logistic regression model demonstrated an increased odds ratio of having HS diagnosis in the AD group as compared with the control non-AD group (odds ratio: 5.57, 95% confidence interval: 4.30-7.21, P < .001).
UNASSIGNED: This was a retrospective study performed at a single institution with the possibility of surveillance bias being present.
UNASSIGNED: Patients with AD are more likely to be diagnosed with HS than patients without AD. Further research is needed to understand the pathophysiologic mechanism and potential treatment implications.
摘要：
■化脓性汗腺炎（HS）和特应性皮炎（AD）都是慢性炎症性皮肤病。这两种情况之间的关联可能对阐明发病机理具有重要的潜在意义。病程,和治疗。
■研究AD和HS之间的关联。
我们对2007年至2017年在杜克大学医学中心就诊的患有AD的患者与未诊断为AD的对照组进行了回顾性队列研究。AD和HS的关联是在调整了其他混杂因素后使用逻辑回归模型评估的，包括年龄，性别,和种族。
■在28,780名诊断为AD的患者中，非AD组的48,383例患者中有325例（1.1％）被诊断为HS，而非AD组的患者中有76例（0.2％）被诊断为HS。调整后的逻辑回归模型显示，与对照组非AD组相比，AD组诊断为HS的比值比增加（比值比：5.57，95％置信区间：4.30-7.21，P<.001）。
■这是一项在单一机构进行的回顾性研究，可能存在监测偏倚。
■AD患者比没有AD的患者更有可能被诊断为HS。需要进一步的研究来了解病理生理机制和潜在的治疗意义。
■研究AD和HS之间的关联。
我们对2007年至2017年在杜克大学医学中心就诊的患有AD的患者与未诊断为AD的对照组进行了回顾性队列研究。AD和HS的关联是在调整了其他混杂因素后使用逻辑回归模型评估的，包括年龄，性别,和种族。
■在28,780名诊断为AD的患者中，非AD组的48,383例患者中有325例（1.1％）被诊断为HS，而非AD组的患者中有76例（0.2％）被诊断为HS。调整后的逻辑回归模型显示，与对照组非AD组相比，AD组诊断为HS的比值比增加（比值比：5.57，95％置信区间：4.30-7.21，P<.001）。
■这是一项在单一机构进行的回顾性研究，可能存在监测偏倚。
■AD患者比没有AD的患者更有可能被诊断为HS。需要进一步的研究来了解病理生理机制和潜在的治疗意义。
