Anti-PL-7 antibody-positive dermatomyositis with progressive interstitial pneumonia complicated with tracheal ulcer.

抗 PL - 7 抗体阳性皮肌炎伴进行性间质性肺炎并发气管溃疡.

• 发表时间: 2021
• 来源期刊: Respir Med Case Rep
• DOI: 10.1016/j.rmcr.2021.101449
• PMID: 34401288
• 文章类型: Case Reports
• 作者列表: Sato S,Yamakawa H,Takemura T,Nakamura T,Oba T,Nishizawa T,Kawabe R,Akasaka K,Amano M,Matsushima H

关键词: ARS, anti-aminoacyl tRNA synthetase; DM, dermatomyositis; Dermatomyositis; GGO, ground-glass opacity; IIM, idiopathic inflammatory myopathy; ILD, interstitial lung disease; Idiopathic inflammatory myopathy; Interstitial pneumonia; MDA5, melanoma-differentiation-associated gene 5; PM, polymyositis; Tracheal ulcer

Abstract

Tracheobronchial lesions are rare extramuscular complications for idiopathic inflammatory myopathies including dermatomyositis. We herein report a 65-year-old woman with tracheal ulcer during the progression of dermatomyositis-associated interstitial lung disease. Treatment with corticosteroids combined with immunosuppressive agents resulted in improvement of the tracheal ulcer and pulmonary involvement. We believe that the tracheal ulceration might reflect the disease behaviour of dermatomyositis and dermatomyositis-associated interstitial pneumonia.

摘要

气管支气管病变是包括皮肌炎在内的特发性炎性肌病的罕见肌外并发症。我们在此报告了一名65岁的女性，在皮肌炎相关的间质性肺病进展期间患有气管溃疡。皮质类固醇联合免疫抑制剂治疗可改善气管溃疡和肺部受累。我们认为气管溃疡可能反映了皮肌炎和皮肌炎相关间质性肺炎的疾病行为。