PDF(Sci-hub)
Abstract：
To study how demographic differences impact disease manifestation of sarcoidosis using the WASOG tool in a large multicentric study.
Clinical data regarding 1445 patients with sarcoidosis from 14 clinical sites in 10 countries were prospectively reviewed from Feb 1, 2020 to Sep 30, 2020. Organ involvement was evaluated for the whole group and for subgroups differentiated by sex, race, and age.
The median age of the patients at diagnosis was 46 years old; 60.8% of the patients were female. The most commonly involved organ was lung (96%), followed by skin (24%) and eye (22%). Black patients had more multiple organ involvement than White patients (OR = 3.227, 95% CI: 2.243-4.643) and females had more multiple organ involvement than males (OR = 1.238, 95% CI: 1.083-1.415). Black patients had more frequent involvement of neurologic, skin, eye, extra thoracic lymph node, liver and spleen than White and Asian patients. Women were more likely to have eye (OR = 1.522, 95%CI: 1.259-1.838) or skin involvement (OR = 1.369, 95%CI: 1.152-1.628). Men were more likely to have cardiac involvement (OR = 1.326, 95%CI: 1.096-1.605). A total of 262 (18.1%) patients did not receive systemic treatment for sarcoidosis. Therapy was more common in Black patients than in other races.
The initial presentation and treatment of sarcoidosis was related to sex, race, and age. Black and female individuals are found to have multiple organ involvement more frequently. Age at diagnosis<45, Black patients and multiple organ involvement were independent predictors of treatment.
Clinical data regarding 1445 patients with sarcoidosis from 14 clinical sites in 10 countries were prospectively reviewed from Feb 1, 2020 to Sep 30, 2020. Organ involvement was evaluated for the whole group and for subgroups differentiated by sex, race, and age.
The median age of the patients at diagnosis was 46 years old; 60.8% of the patients were female. The most commonly involved organ was lung (96%), followed by skin (24%) and eye (22%). Black patients had more multiple organ involvement than White patients (OR = 3.227, 95% CI: 2.243-4.643) and females had more multiple organ involvement than males (OR = 1.238, 95% CI: 1.083-1.415). Black patients had more frequent involvement of neurologic, skin, eye, extra thoracic lymph node, liver and spleen than White and Asian patients. Women were more likely to have eye (OR = 1.522, 95%CI: 1.259-1.838) or skin involvement (OR = 1.369, 95%CI: 1.152-1.628). Men were more likely to have cardiac involvement (OR = 1.326, 95%CI: 1.096-1.605). A total of 262 (18.1%) patients did not receive systemic treatment for sarcoidosis. Therapy was more common in Black patients than in other races.
The initial presentation and treatment of sarcoidosis was related to sex, race, and age. Black and female individuals are found to have multiple organ involvement more frequently. Age at diagnosis<45, Black patients and multiple organ involvement were independent predictors of treatment.
摘要：
在一项大型多中心研究中，使用WASOG工具研究人口统计学差异如何影响结节病的疾病表现。
从2020年2月1日至2020年9月30日，前瞻性回顾了来自10个国家14个临床地点的1445例结节病患者的临床数据。评估了整个组和按性别区分的亚组的器官受累情况，种族,和年龄。
诊断时患者的中位年龄为46岁；60.8%的患者为女性。最常见的器官是肺（96%），其次是皮肤（24％）和眼睛（22％）。黑人患者的多器官受累多于白人患者（OR=3.227，95％CI：2.243-4.643），女性患者的多器官受累多于男性（OR=1.238，95％CI：1.083-1.415）。黑人患者更频繁地涉及神经系统，皮肤,眼睛,胸外淋巴结,肝脏和脾脏比白色和亚洲患者。女性更容易出现眼睛（OR=1.522，95CI：1.259-1.838）或皮肤受累（OR=1.369，95CI：1.152-1.628）。男性更容易发生心脏受累(OR=1.326,95CI:1.096-1.605)。共有262例（18.1％）患者未接受结节病的全身治疗。治疗在黑人患者中比在其他种族中更常见。
结节病的最初表现和治疗与性别有关，种族,和年龄。发现黑人和女性个体更频繁地涉及多器官。诊断年龄<45岁，Black患者和多器官受累是治疗的独立预测因素。
从2020年2月1日至2020年9月30日，前瞻性回顾了来自10个国家14个临床地点的1445例结节病患者的临床数据。评估了整个组和按性别区分的亚组的器官受累情况，种族,和年龄。
诊断时患者的中位年龄为46岁；60.8%的患者为女性。最常见的器官是肺（96%），其次是皮肤（24％）和眼睛（22％）。黑人患者的多器官受累多于白人患者（OR=3.227，95％CI：2.243-4.643），女性患者的多器官受累多于男性（OR=1.238，95％CI：1.083-1.415）。黑人患者更频繁地涉及神经系统，皮肤,眼睛,胸外淋巴结,肝脏和脾脏比白色和亚洲患者。女性更容易出现眼睛（OR=1.522，95CI：1.259-1.838）或皮肤受累（OR=1.369，95CI：1.152-1.628）。男性更容易发生心脏受累(OR=1.326,95CI:1.096-1.605)。共有262例（18.1％）患者未接受结节病的全身治疗。治疗在黑人患者中比在其他种族中更常见。
结节病的最初表现和治疗与性别有关，种族,和年龄。发现黑人和女性个体更频繁地涉及多器官。诊断年龄<45岁，Black患者和多器官受累是治疗的独立预测因素。
