PDF(Pubmed)
Abstract：
Indonesia has the second largest tuberculosis (TB) burden globally. Attempts to scale-up TB control efforts have focused on TB households. However, in most high burden settings, considerable Mycobacterium tuberculosis (Mtb) transmission occurs outside TB households. A better understanding of transmission dynamics in an urban setting in Indonesia will be crucial for the TB Control Program in scaling up efforts towards elimination of TB in a more targeted way. Therefore, the study aims to measure TB prevalence and incidence in household contacts and neighbourhoods in the vicinity of known TB cases and to assess their genomic and epidemiological relatedness.
Individuals (~1000) living in the same household as a case diagnosed with pulmonary TB (n = 250) or in a neighbouring household (~4500 individuals) will be screened for TB symptoms and by chest x-ray. Two sputum samples will be collected for microbiological analysis from anyone with a productive cough. Any person found to have TB will be treated by the National TB Control Program. All those with no evidence of TB disease will have a repeat screen at 12 months. Whole-genome sequencing (WGS) and social network analysis (SNA) will be conducted on Index cases and contacts diagnosed with TB.
Individuals (~1000) living in the same household as a case diagnosed with pulmonary TB (n = 250) or in a neighbouring household (~4500 individuals) will be screened for TB symptoms and by chest x-ray. Two sputum samples will be collected for microbiological analysis from anyone with a productive cough. Any person found to have TB will be treated by the National TB Control Program. All those with no evidence of TB disease will have a repeat screen at 12 months. Whole-genome sequencing (WGS) and social network analysis (SNA) will be conducted on Index cases and contacts diagnosed with TB.
摘要：
印度尼西亚是全球第二大结核病（TB）负担。扩大结核病控制工作的尝试集中在结核病家庭。然而,在大多数高负担环境中，大量的结核分枝杆菌（Mtb）传播发生在结核病家庭之外。更好地了解印度尼西亚城市环境中的传播动态对于结核病控制计划以更有针对性的方式扩大消除结核病的努力至关重要。因此,该研究旨在测量已知结核病例附近家庭接触者和社区的结核病患病率和发病率,并评估其基因组和流行病学相关性.
将对与诊断为肺结核患者（n=250）或邻近家庭（约4500人）生活在同一家庭中的个体（约1000人）进行TB症状筛查和胸部X光检查。将从任何患有生产性咳嗽的人收集两个痰样本用于微生物学分析。任何被发现患有结核病的人都将接受国家结核病控制计划的治疗。所有没有结核病证据的人将在12个月时进行重复筛查。全基因组测序（WGS）和社会网络分析（SNA）将对诊断为结核病的索引病例和接触者进行。
将对与诊断为肺结核患者（n=250）或邻近家庭（约4500人）生活在同一家庭中的个体（约1000人）进行TB症状筛查和胸部X光检查。将从任何患有生产性咳嗽的人收集两个痰样本用于微生物学分析。任何被发现患有结核病的人都将接受国家结核病控制计划的治疗。所有没有结核病证据的人将在12个月时进行重复筛查。全基因组测序（WGS）和社会网络分析（SNA）将对诊断为结核病的索引病例和接触者进行。
