红系线粒体滞留触发人 SLE 中骨髓依赖性 I 型干扰素。
关键词: CANDLE syndrome HIF2a autoimmunity cGAS human erythropoiesis interferon mitochondrial DNA mitophagy proteasome systemic lupus erythematosus
Mesh : Adolescent Basic Helix-Loop-Helix Transcription Factors / metabolism Child Child, Preschool Erythroblasts / metabolism ultrastructure Erythrocytes / metabolism Erythropoiesis Humans Interferon Type I / metabolism Lupus Erythematosus, Systemic / metabolism Mitochondria / metabolism Mitophagy Myeloid Cells / metabolism Proteasome Endopeptidase Complex / metabolism Ubiquitin / metabolism
来 源:
DOI:10.1016/j.cell.2021.07.021
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