cGAS - STING 信号在肝脏疾病中的作用。
关键词: AIM2, absent in melanoma 2 ALD, alcohol-related liver disease APCs, antigen-presenting cells CDNs, cyclic dinucleotides DAMPs, damage-associated molecular patterns DCs, dendritic cells ER, endoplasmic reticulum GVHD, graft-versus-host disease HCC, hepatocellular carcinoma HSCs, hepatic stellate cells IFN-I, type I interferon IL, interleukin IRF3, interferon regulatory factor 3 IRI, ischaemia refusion injury KCs, Kupffer cells LSECs, liver sinusoidal endothelial cells MHC, major histocompatibility complex NAFLD, non-alcoholic fatty liver disease NK cells, natural killer cells NPCs, non-parenchymal cells PAMPs, pathogen-associated molecular patterns PD-1, programmed cell death protein-1 PD-L1, programmed cell death protein ligand-1 PPRs, pattern recognition receptors SAVI, STING-associated vasculopathy with onset in infancy STING, stimulator of interferon genes TBK1, TANK-binding kinase 1 TGF-β1, transforming growth factor-β1 TLR, Toll-like receptor TNF, tumour necrosis factor XRCC, X-ray repair cross complementing aHSCT, allogeneic haematopoietic stem cell transplantation cGAMP, cyclic guanosine monophosphate-adenosine monophosphate cGAS, cyclic guanosine monophosphate-adenosine monophosphate synthase cGAS-STING signalling dsDNA, double-strand DNA hepatocellular carcinoma innate immune response liver injury mTOR, mammalian target of rapamycin mtDNA, mitochondrial DNA nonalcoholic fatty liver disease siRNA, small interfering RNA ssRNA, single-stranded RNA viral hepatitis
来 源:
DOI:10.1016/j.jhepr.2021.100324
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