PDF(Pubmed)
Abstract：
Gene expression and translation have been extensively studied in human post-mortem brain tissue from subjects with psychiatric disease. Post-translational modifications (PTMs) have received less attention despite their implication by unbiased genetic studies and importance in regulating neuronal and circuit function. Here we review the rationale for studying PTMs in psychiatric disease, recent findings in human post-mortem tissue, the required controls for these types of studies, and highlight the emerging mass spectrometry approaches transforming this research direction.
摘要：
已经在患有精神疾病的受试者的人类死后脑组织中广泛研究了基因表达和翻译。翻译后修饰（PTM）受到的关注较少，尽管无偏见的遗传研究和调节神经元和回路功能的重要性。在这里，我们回顾了研究精神疾病中PTM的基本原理，在人类死后组织中的最新发现，这些类型的研究所需的控制，并强调了新兴的质谱方法改变了这一研究方向。
