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Abstract：
Silver nanoparticles (AgNPs) have recently emerged as promising growth promoters and immune-lifting agents in the poultry industry. This study investigated the potential impact of AgNP supplementation in the drinking water (DW) of broiler chickens during the fattening period. AgNPs were produced through chemical reduction using starch as a reducing and stabilizing agent. Different concentrations (1-5 ppm) of AgNPs were prepared and added to the DW of five different groups of chickens. Results confirmed efficient and safe application of AgNPs in DW at concentrations up to 2 ppm in term of growth performance (body weight, body weight gain, and feed conversion ratio) and hematological parameters. However, higher concentrations (3-5 ppm) induced dose-dependent mild-to-moderate adverse effects on hematological, biochemical, and oxidative parameters (MDA, TAC, and GSH-px). While growth performance, gene expression of fibroblast growth factor 2 (FGF2), vascular endothelial growth factor A (VEGFA),and insulin-like growth factor (IGF1) in muscle, histopathological and immunohistochemical evaluation of liver, kidney, spleen, bursa, and thymus, and ultrastructural analysis of breast muscle were not significantly affected, even at high concentrations of AgNPs. Therefore, supplementation of AgNPs up to 2 ppm in the DW of broilers is promising.
摘要：
银纳米颗粒（AgNP）最近在家禽业中作为有前途的生长促进剂和免疫提升剂出现。这项研究调查了在育肥期间在肉鸡的饮用水（DW）中补充AgNP的潜在影响。使用淀粉作为还原剂和稳定剂通过化学还原产生AgNP。制备不同浓度(1-5ppm)的AgNP,并将其添加到5个不同组的鸡的DW中。结果证实，就生长性能（体重，体重增加,和饲料转化率）和血液学参数。然而,较高浓度（3-5ppm）对血液学产生剂量依赖性轻度至中度不良反应，生物化学，和氧化参数(MDA，TAC,和GSH-px）。虽然增长业绩，成纤维细胞生长因子2（FGF2）的基因表达，血管内皮生长因子A(VEGFA),和肌肉中的胰岛素样生长因子（IGF1），肝脏的组织病理学和免疫组织化学评估，肾,脾,脾Bursa,还有胸腺,和超微结构分析的乳房肌肉没有明显的影响，即使在高浓度的AgNPs。因此,在肉鸡的DW中补充高达2ppm的AgNPs是有希望的。
