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Abstract：
C6O4 (difluoro{[2,2,4,5-tetrafluoro-5-(trifluoromethoxy)-1,3-dioxolan-4-yl]oxy}acetic acid) is a new surfactant and emulsifier used as a substitute of perfluorooctanoic acid (PFOA). Recently, C6O4 has been detected in aquatic environments, but, at present, no information concerning the effects of C6O4 on aquatic species, such as bivalves, are available in the literature. Therefore, in this study we evaluated for the first time the effects of C6O4 (0.1 and 1 µg/L) and PFOA (1 µg/L) to the clam Ruditapes philippinarum. Short-term (7 days) and long-term (21 days) exposures of clams to the two compounds were carried out and numerous biomarkers were measured in haemocytes/haemolymph, as well as in gills and digestive gland. The MANOVA analysis demonstrated statistically significant effects of the independent variables \"treatment\", \"time\" and \"treatment-time interaction\" on the whole dataset of biomarker responses. The two-way ANOVA analysis performed for each biomarker response indicated that the two compounds affected most of the cellular and tissue parameters measured. Despite preliminary, the results obtained suggested that C6O4 - similarly to PFOA - can affect both cellular and biochemical parameters of clams.
摘要：
C6O4（二氟{[2,2,4,5-四氟-5-（三氟甲氧基）-1,3-二氧戊环-4-基]氧基}乙酸）是一种新型表面活性剂和乳化剂，可用作全氟辛酸（PFOA）的替代品。最近,在水生环境中检测到C6O4，但是,目前,没有关于C6O4对水生物种影响的信息，比如双壳类动物，可以在文献中找到。因此,在这项研究中，我们首次评估了C6O4（0.1和1µg/L）和PFOA（1µg/L）对菲律宾蛤仔的影响。进行了对两种化合物的短期（7天）和长期（21天）接触，并在血细胞/血淋巴中测量了许多生物标志物。以及ill和消化腺。MANOVA分析表明独立变量“治疗”的统计学显着影响，生物标志物反应的整个数据集上的“时间”和“治疗-时间相互作用”。对每个生物标记物响应进行的双向ANOVA分析表明,两种化合物影响测量的大多数细胞和组织参数。尽管初步的,获得的结果表明，C6O4-类似于PFOA-可以影响蛤仔的细胞和生化参数。
