Human Monocytic Ehrlichiosis Associated With Myocarditis and Hemophagocytic Lymphohistiocytosis.

人单核细胞埃里希菌病与心肌炎和噬血细胞淋巴组织细胞增多症相关。

• 发表时间: Mar 2020
• 来源期刊: JACC Case Rep
• DOI: 10.1016/j.jaccas.2019.12.042
• PMID: 34317254
• 文章类型: Case Reports
• 作者列表: Dahm CN,Yang BQ,Clark DE,Armstrong WC,Stevenson LW

关键词: ECG, electrocardiogram; EF, ejection fraction; HD, hospital day; HLH, hemophagocytic lymphohistiocytosis; HME, human monocytic ehrlichiosis; IV, intravenous; LV, left ventricular; OSH, outside hospital; PCR, polymerase chain reaction; TTE, transthoracic echocardiogram; cardiomyopathy; echocardiography; electrocardiogram

Abstract

We present 3 cases at a single institution of human monocytic ehrlichiosis resulting in myocarditis and hemophagocytic lymphohistiocytosis. Contrary to previously published studies in which case fatalities were only as high as 1%, 2 of the 3 patients we discuss experienced a fulminant course resulting in death despite appropriate doxycycline treatment. Human monocytic ehrlichiosis is rarely a cause of myocarditis and hemophagocytic lymphohistiocytosis, but a high degree of suspicion is important because early empirical therapy may decrease morbidity and mortality. (Level of Difficulty: Intermediate.).

摘要

我们介绍了3例人类单核细胞埃希氏病的单个机构，导致心肌炎和噬血细胞淋巴组织细胞增多症。与以前发表的案例死亡率仅为1%的研究相反，尽管进行了适当的多西环素治疗，但我们讨论的3例患者中有2例经历了暴发性过程，导致死亡。人单核细胞埃希氏病很少是心肌炎和噬血细胞淋巴组织细胞增多症的原因，但高度怀疑是重要的，因为早期经验治疗可以降低发病率和死亡率。（难度等级：中级。).