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Abstract：
Metabolic disorders in children after hematopoietic stem cell transplantation (HSCT) are poorly characterized. However, it is known that dyslipidemia and insulin resistance are particularly common in these patients. We conducted a prospective study of 27 patients treated with HSCT to assess the possibility of predicting these abnormalities. We measured gene expressions using a microarray technique to identify differences in expression of genes associated with lipid metabolism before and after HSCT. In patients treated with HSCT, total cholesterol levels were significantly higher after the procedure compared with the values before HSCT. Microarray analysis revealed statistically significant differences in expressions of three genes, DPP4, PLAG1, and SCD, after applying the Benjamini-Hochberg procedure (pBH < 0.05). In multiple logistic regression, the increase of DPP4 gene expression before HCST (as well as its change between pre- and post-HSCT status) was associated with dyslipidemia. In children treated with HSCT, the burden of lipid disorders in short-term follow-up seems to be lower than before the procedure. The expression pattern of DPP4 is linked with dyslipidemia after the transplantation.
摘要：
造血干细胞移植（HSCT）后儿童的代谢紊乱特征不明确。然而,众所周知，血脂异常和胰岛素抵抗在这些患者中特别常见。我们对27例接受HSCT治疗的患者进行了一项前瞻性研究，以评估预测这些异常的可能性。我们使用微阵列技术测量基因表达，以鉴定HSCT前后与脂质代谢相关基因表达的差异。在接受HSCT治疗的患者中，术后总胆固醇水平明显高于HSCT前.微阵列分析显示三个基因的表达差异具有统计学意义，DPP4、PLAG1和SCD，在应用Benjamini-Hochberg程序后（pBH<0.05）。在多元逻辑回归中，HCST前DPP4基因表达的增加(以及HSCT前后状态的变化)与血脂异常相关.在接受HSCT治疗的儿童中，短期随访中的血脂紊乱负担似乎低于手术前.移植后DPP4的表达模式与血脂异常有关。
