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Abstract：
Whilst up to 60% of males with fragile X syndrome (FXS) meet criteria for autism spectrum disorder (ASD), the prevalence and nature of ASD in females with FXS remains unclear.
A systematic literature search identified papers reporting ASD prevalence and/or symptomatology in females with FXS.
Meta-analysis suggested that rates of ASD for females with FXS are reliably higher than for females in the general population (a random effects model estimated weighted average prevalence at 14%, 95% CI 13-18%). Whilst papers highlighted a number of social and repetitive difficulties for females with FXS, characteristic profiles of impairment are not clear. Possible associations between ASD traits and IQ, and between ASD and levels of fragile X mental retardation protein, are suggested, but data are equivocal.
A systematic literature search identified papers reporting ASD prevalence and/or symptomatology in females with FXS.
Meta-analysis suggested that rates of ASD for females with FXS are reliably higher than for females in the general population (a random effects model estimated weighted average prevalence at 14%, 95% CI 13-18%). Whilst papers highlighted a number of social and repetitive difficulties for females with FXS, characteristic profiles of impairment are not clear. Possible associations between ASD traits and IQ, and between ASD and levels of fragile X mental retardation protein, are suggested, but data are equivocal.
摘要：
虽然高达60％的患有脆性X综合征（FXS）的男性符合自闭症谱系障碍（ASD）的标准，女性FXS患者ASD的患病率和性质尚不清楚.
系统的文献检索确定了报告FXS女性ASD患病率和/或症状学的论文。
荟萃分析表明，女性FXS患者的ASD发生率可靠地高于普通人群中的女性（随机效应模型估计加权平均患病率为14％，95%CI13-18%）。虽然论文强调了FXS女性面临的一些社会和重复性困难，损害的特征特征不清楚。ASD特征和智商之间可能存在关联，在ASD和脆性X智力低下蛋白水平之间，建议，但是数据是模棱两可的。
系统的文献检索确定了报告FXS女性ASD患病率和/或症状学的论文。
荟萃分析表明，女性FXS患者的ASD发生率可靠地高于普通人群中的女性（随机效应模型估计加权平均患病率为14％，95%CI13-18%）。虽然论文强调了FXS女性面临的一些社会和重复性困难，损害的特征特征不清楚。ASD特征和智商之间可能存在关联，在ASD和脆性X智力低下蛋白水平之间，建议，但是数据是模棱两可的。
