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Abstract：
Colchicine\'s medical evolution is historically bound to the Mediterranean basin, since remarkable researchers from this region underscored its valuable properties. With the passing of years colchicine became an essential pharmaceutical substance for the treatment of rheumatologic and cardiovascular diseases. In light of recent findings, the therapeutic value of colchicine has grown. In clinical practice, colchicine remains underutilized in view of its proven efficacy and safety. Its complex pharmacokinetics and multifaceted anti-inflammatory role remain under investigation. The current review addresses the safe administration of colchicine in view of key drug to drug interactions. Finally, we are briefly presenting colchicine\'s future potential applications.
摘要：
秋水仙碱的医学进化在历史上与地中海盆地有关，因为来自该地区的杰出研究人员强调了其宝贵的特性。随着岁月的流逝，秋水仙碱成为治疗风湿病和心血管疾病的必需药物。根据最近的发现,秋水仙碱的治疗价值已经增长。在临床实践中,鉴于秋水仙碱已被证明的疗效和安全性，秋水仙碱仍未得到充分利用。其复杂的药代动力学和多方面的抗炎作用仍在研究中。鉴于关键药物与药物的相互作用，当前的综述讨论了秋水仙碱的安全给药。最后,我们将简要介绍秋水仙碱未来的潜在应用。
