PDF(Pubmed)
Abstract：
Sensitivity to satiety constitutes a basic requirement for neuronal coding of subjective reward value. Satiety from natural ongoing consumption affects reward functions in learning and approach behavior. More specifically, satiety reduces the subjective economic value of individual rewards during choice between options that typically contain multiple reward components. The unconfounded assessment of economic reward value requires tests at choice indifference between two options, which is difficult to achieve with sated rewards. By conceptualizing choices between options with multiple reward components (\"bundles\"), Revealed Preference Theory may offer a solution. Despite satiety, choices against an unaltered reference bundle may remain indifferent when the reduced value of a sated bundle reward is compensated by larger amounts of an unsated reward of the same bundle, and then the value loss of the sated reward is indicated by the amount of the added unsated reward. Here, we show psychophysically titrated choice indifference in monkeys between bundles of differently sated rewards. Neuronal chosen value signals in the orbitofrontal cortex (OFC) followed closely the subjective value change within recording periods of individual neurons. A neuronal classifier distinguishing the bundles and predicting choice substantiated the subjective value change. The choice between conventional single rewards confirmed the neuronal changes seen with two-reward bundles. Thus, reward-specific satiety reduces subjective reward value signals in OFC. With satiety being an important factor of subjective reward value, these results extend the notion of subjective economic reward value coding in OFC neurons.
摘要：
对饱腹感的敏感性构成了对主观奖励值的神经元编码的基本要求。自然持续消费的满足感会影响学习和接近行为中的奖励功能。更具体地说,在选择通常包含多个奖励成分的选项时，饱腹感降低了个人奖励的主观经济价值。对经济回报价值的无混淆评估需要测试两种选择之间的选择冷漠，这是很难实现与满足的奖励。通过概念化具有多个奖励组件(“捆绑包”)的选项之间的选择，揭示的偏好理论可以提供一个解决方案。尽管饱腹感,选择对一个不变的参考束可能保持无动于衷时，一个已分配的束奖励的减少的价值是由较大量的相同束的未分配的奖励补偿，然后用增加的未支付奖励的金额来表示支付奖励的价值损失。这里,我们显示了猴子在不同状态的奖励之间的心理物理滴定选择冷漠。眶额叶皮层（OFC）中的神经元选择值信号紧随单个神经元记录周期内的主观值变化。区分束并预测选择的神经元分类器证实了主观值的变化。传统的单一奖励之间的选择证实了两个奖励束看到的神经元变化。因此，特定于奖励的饱腹感降低了OFC中的主观奖励值信号。饱腹感是主观奖励价值的重要因素，这些结果扩展了OFC神经元中主观经济报酬值编码的概念。
