Abstract：
OBJECTIVE: To determine the association and the prognostic value of soluble ST2 (sST2) levels in the development of diabetic retinopathy (DR), diabetic macular oedema (DMO) or diabetic nephropathy (DN), in a cohort of patients with type 1 diabetes (T1D).
METHODS: A total of 269 individuals with T1D (154 males and 115 females) were recruited. The overall mean age was 43.2±14.9 years, and the diabetes duration was 17.1±12.1 years. Levels of sST2 in serum were evaluated, and the presence as well as the degree of DR, DMO and DN was recorded. Additionally, other clinical and analytical parameters including demographic variables were recovered from patients\' electronic health record. Ten years later, the presence and stage of DR, DMO and DN were again recorded under the same criteria. The association between previously mentioned parameters with DR and DN was analysed by univariate and multivariate logistic regression. The variables in the final multivariate models were adjusted from complete models via backward elimination and maintained only when significant.
RESULTS: An increase of 10ng/ml in the levels of sST2 was associated with a 1.50 (1.02-2.19) and 1.48 (1.05-2.08) prevalence odds ratio (OR) in DMO and DR, respectively. There was no association between sST2 levels and DN. Meanwhile, sST2 levels did not display a prognostic effect in any of the microangiopathic diabetic complications studied.
CONCLUSIONS: Levels of sST2 are associated with the presence of DR and DMO, they do not seem to be predictive for the development or deterioration of DR, DMO or DN.
METHODS: A total of 269 individuals with T1D (154 males and 115 females) were recruited. The overall mean age was 43.2±14.9 years, and the diabetes duration was 17.1±12.1 years. Levels of sST2 in serum were evaluated, and the presence as well as the degree of DR, DMO and DN was recorded. Additionally, other clinical and analytical parameters including demographic variables were recovered from patients\' electronic health record. Ten years later, the presence and stage of DR, DMO and DN were again recorded under the same criteria. The association between previously mentioned parameters with DR and DN was analysed by univariate and multivariate logistic regression. The variables in the final multivariate models were adjusted from complete models via backward elimination and maintained only when significant.
RESULTS: An increase of 10ng/ml in the levels of sST2 was associated with a 1.50 (1.02-2.19) and 1.48 (1.05-2.08) prevalence odds ratio (OR) in DMO and DR, respectively. There was no association between sST2 levels and DN. Meanwhile, sST2 levels did not display a prognostic effect in any of the microangiopathic diabetic complications studied.
CONCLUSIONS: Levels of sST2 are associated with the presence of DR and DMO, they do not seem to be predictive for the development or deterioration of DR, DMO or DN.
摘要：
目的：确定可溶性ST2（sST2）水平在糖尿病视网膜病变（DR）发展中的相关性和预后价值。糖尿病性黄斑水肿（DMO）或糖尿病肾病（DN），在1型糖尿病（T1D）患者队列中。
方法：共招募了269名T1D患者（男性154名，女性115名）。总体平均年龄为43.2±14.9岁，糖尿病病程为17.1±12.1年。评估血清中sST2的水平，以及DR的存在和程度，记录DMO和DN。此外,我们从患者电子健康记录中恢复了其他临床和分析参数,包括人口统计学变量.十年后,DR的存在和阶段，在相同的标准下再次记录DMO和DN。通过单变量和多变量逻辑回归分析先前提到的参数与DR和DN之间的关联。最终多变量模型中的变量通过反向消除从完整模型中进行调整，并且仅在显着时保持。
结果：sST2水平增加10ng/ml与DMO和DR的1.50（1.02-2.19）和1.48（1.05-2.08）患病率比值比（OR）相关。分别。sST2水平与DN之间没有关联。同时,在所研究的任何微血管病性糖尿病并发症中，sST2水平均未显示出预后效果。
结论：sST2水平与DR和DMO的存在有关，它们似乎不能预测DR的发展或恶化，DMO或DN。
方法：共招募了269名T1D患者（男性154名，女性115名）。总体平均年龄为43.2±14.9岁，糖尿病病程为17.1±12.1年。评估血清中sST2的水平，以及DR的存在和程度，记录DMO和DN。此外,我们从患者电子健康记录中恢复了其他临床和分析参数,包括人口统计学变量.十年后,DR的存在和阶段，在相同的标准下再次记录DMO和DN。通过单变量和多变量逻辑回归分析先前提到的参数与DR和DN之间的关联。最终多变量模型中的变量通过反向消除从完整模型中进行调整，并且仅在显着时保持。
结果：sST2水平增加10ng/ml与DMO和DR的1.50（1.02-2.19）和1.48（1.05-2.08）患病率比值比（OR）相关。分别。sST2水平与DN之间没有关联。同时,在所研究的任何微血管病性糖尿病并发症中，sST2水平均未显示出预后效果。
结论：sST2水平与DR和DMO的存在有关，它们似乎不能预测DR的发展或恶化，DMO或DN。
