PDF(Pubmed)
Abstract：
Objective: The aim of this meta-analysis was to investigate retinal microvascular features in patients with Alzheimer\'s disease (AD) using optical coherence tomography angiography (OCTA). Methods: PubMed, Cochrane Library, Embase, and Web of Science databases were systematically searched for published articles comparing retinal microvascular characteristics in subjects with AD and controls. The mean difference (MD) with a 95% confidence interval (CI) was used to assess continuous variables. Review Manager Version (RevMan) 5.30, was employed to analyze the data. Results: Nine studies were included in the meta-analysis. The analysis revealed that the macular whole enface superficial and deep vessel density (VD) values measured by OCTA were significantly lower in patients with AD than in controls (MD = -1.10, P < 0.0001; MD = -1.61, P = 0.0001, respectively). The value measured by OCTA for parafoveal superficial VD in patients with AD was also remarkably lower than that in the control group (MD = -1.42, P = 0.001), whereas there was no significant difference in the value for parafoveal deep VD (MD = -3.67, P = 0.19), compared to the controls. In addition, the foveal avascular zone (FAZ) was larger in patients with AD than in the control group (MD = 0.08, P = 0.07), although it did not reach statistical significance. Conclusions: The present meta-analysis indicated that the macular whole enface and parafoveal vessel densities were reduced in patients with AD. Moreover, our pooled data revealed that FAZ is larger in patients with AD. Consequently, OCTA may be utilized as a diagnostic tool to identify and monitor patients with AD.
摘要：
目的：本荟萃分析的目的是使用光学相干断层扫描血管造影（OCTA）研究阿尔茨海默病（AD）患者的视网膜微血管特征。方法:PubMed,科克伦图书馆,Embase,和WebofScience数据库被系统地搜索发表的文章，比较患有AD和对照的受试者的视网膜微血管特征。使用具有95%置信区间(CI)的平均差(MD)来评估连续变量。采用审查管理器版本(RevMan)5.30来分析数据。结果：9项研究纳入荟萃分析。分析显示，AD患者OCTA测量的黄斑全表面浅表和深血管密度（VD）值显着低于对照组（MD=-1.10，P<0.0001；MD=-1.61，P=0.0001）。OCTA对AD患者的旁凹浅层VD的测量值也明显低于对照组（MD=-1.42，P=0.001）。而前凹深VD值无显著差异(MD=-3.67,P=0.19),与对照组相比。此外,AD患者的中央凹无血管区（FAZ）大于对照组（MD=0.08，P=0.07），虽然没有达到统计学意义。结论：目前的荟萃分析表明，AD患者的黄斑全表面和旁凹血管密度降低。此外，我们汇总的数据显示,AD患者的FAZ更大.因此,OCTA可用作诊断工具以识别和监测患有AD的患者。
