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Abstract：
A pathognomonic macular ripple sign has been reported with scanning laser ophthalmoscopy images in patients with foveal hypoplasia, though the optical basis of this sign is presently unknown. Here we present a case series of seven individuals with foveal hypoplasia (based on spectral domain optical coherence tomography). Each patient underwent infrared scanning laser ophthalmoscopy retinal imaging in both eyes, acquired with and without a polarization filter and assessment for a ripple-like effect in the fovea. On imaging, macular ripples were present in all eyes with foveal hypoplasia when using a polarization filter, but not when imaged without the filter. We conclude that the macular ripple sign is an imaging artifact attributable to the unique pattern of phase retardation of the Henle fiber layer in the setting of foveal hypoplasia. By utilizing a polarization filter with retinal photography, this feature can be exploited to promptly identify foveal hypoplasia in settings where OCT is not possible due to nystagmus.
摘要：
在中央凹发育不全的患者中，通过扫描激光检眼镜检查图像已报道了病理性黄斑波纹征，虽然这个标志的光学基础目前是未知的。在这里，我们介绍了七个患有中央凹发育不全的个体的病例系列（基于光谱域光学相干断层扫描）。每位患者都进行了双眼红外激光扫描检眼镜视网膜成像，在有和没有偏振滤波器的情况下获得，并评估了中央凹的波纹状效果。在成像方面，当使用偏振滤光片时，所有患有中央凹发育不全的眼睛都出现黄斑波纹，但不是在没有过滤器的情况下成像。我们得出的结论是，在中央凹发育不全的情况下，黄斑波纹征是归因于Henle纤维层相位延迟的独特模式的成像伪影。通过使用偏振滤光片进行视网膜摄影，在由于眼球震颤而无法进行OCT的情况下,可以利用该功能及时识别中央凹发育不全.
