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Abstract：
Magnetic resonance-guided focused ultrasound (MRgFUS) is a completely non-invasive technology that has been approved by FDA to treat several diseases. This report, prepared by the American Association of Physicist in Medicine (AAPM) Task Group 241, provides background on MRgFUS technology with a focus on clinical body MRgFUS systems. The report addresses the issues of interest to the medical physics community, specific to the body MRgFUS system configuration, and provides recommendations on how to successfully implement and maintain a clinical MRgFUS program. The following sections describe the key features of typical MRgFUS systems and clinical workflow and provide key points and best practices for the medical physicist. Commonly used terms, metrics and physics are defined and sources of uncertainty that affect MRgFUS procedures are described. Finally, safety and quality assurance procedures are explained, the recommended role of the medical physicist in MRgFUS procedures is described, and regulatory requirements for planning clinical trials are detailed. Although this report is limited in scope to clinical body MRgFUS systems that are approved or currently undergoing clinical trials in the United States, much of the material presented is also applicable to systems designed for other applications.
摘要：
磁共振引导聚焦超声（MRgFUS）是一种完全非侵入性的技术，已被FDA批准用于治疗多种疾病。这份报告,由美国医学物理学家协会（AAPM）任务组241编写，提供了MRgFUS技术的背景，重点是临床机构MRgFUS系统。该报告解决了医学物理学界感兴趣的问题，特定于车身MRgFUS系统配置，并就如何成功实施和维持临床MRgFUS计划提供建议.以下部分描述了典型MRgFUS系统和临床工作流程的关键特征，并为医学物理学家提供了关键点和最佳实践。常用的术语,定义了度量和物理学，并描述了影响MRgFUS程序的不确定性来源。最后,说明了安全和质量保证程序，描述了医学物理学家在MRgFUS程序中的推荐角色，和规划临床试验的监管要求是详细的。尽管本报告的范围仅限于在美国批准或目前正在进行临床试验的临床机构MRgFUS系统，提供的许多材料也适用于为其他应用设计的系统。
