PDF(Pubmed)
Abstract：
Coronavirus disease 2019 (COVID-19) exhibit mild to moderate symptoms, whereas 15% of COVID-19 cases progress to pneumonia, some associated cutaneous findings are also reported as maculopapular eruptions, morbilliform rashes, urticaria, chickenpox-like lesions, and livedo reticularis. The inactivated COVID-19 vaccines are authorized for use in some countries including Turkey. Here, we report an unusual case of varicella-zoster virus (VZV) reactivation in a 68-year-old male patient who was vaccinated against COVID-19. The patient presented to family medicine clinic with a stinging sensation and pain radiating from the right side of his chest to his back. Physical examination revealed multiple pinheaded vesicular lesions upon an erythematous base occupying an area on his right mammary region and back corresponding to T3-T5 dermatomes. He reported that he got his second dose of COVID-19 vaccine 5 days ago. As COVID 19 decreases the cell-mediated immunity, it could also increase the risk of herpes zoster (HZ). Although the exact reason remains unsolved, vaccine-induced immunomodulation caused by live attenuated vaccines and attenuated alloreactivity caused by inactivated vaccines may be responsible mechanisms for the reactivation of HZ. Epidemiological studies are needed to clarify the possible connection between vaccination and reactivation of herpesvirus infections.
摘要：
2019年冠状病毒病（COVID-19）表现出轻度至中度症状，而15%的COVID-19病例进展为肺炎，一些相关的皮肤发现也被报道为斑丘疹，麻疹病毒状的皮疹，荨麻疹,水痘样病变,和网状livedo.灭活的COVID-19疫苗被授权在包括土耳其在内的一些国家使用。这里,我们报告了一例罕见的水痘-带状疱疹病毒(VZV)再激活病例,该病例是1例68岁男性患者,他接种了COVID-19疫苗.患者出现在家庭医学诊所，刺痛的感觉和疼痛从他的胸部右侧辐射到他的背部。体格检查显示，红斑基底上有多个尖头囊泡病变，位于他的右乳腺区域和背部，对应于T3-T5皮组。他报告说，他在5天前接种了第二剂COVID-19疫苗。随着COVID19降低细胞介导的免疫力，它还可能增加带状疱疹（HZ）的风险。尽管确切的原因仍未解决，由减毒活疫苗引起的疫苗诱导的免疫调节和由灭活疫苗引起的减毒同种异体反应性可能是HZ再激活的机制。需要进行流行病学研究以阐明疫苗接种与疱疹病毒感染的再激活之间的可能联系。
