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Abstract：
In both humans and animal models, consumption of a high-saturated-fat diet has been linked to vascular dysfunction and cognitive impairments. Laboratory animals provide excellent models for more invasive high-fat-diet-related research. However, the physiological differences between humans and common animal models in terms of how they react metabolically to high-fat diets need to be considered. Here, we review the factors that may affect the translatability of mechanistic research in animal models, paying special attention to the effects of a high-fat diet on vascular outcomes. We draw attention to the dissociation between metabolic syndrome and dyslipidemia in rodents, unlike the state in humans, where the two commonly occur. We also discuss the differential vulnerability between species to the metabolic and vascular effects of macronutrients in the diet. Findings from animal studies are better interpreted as modeling specific aspects of dysfunction. We conclude that the differences between species provide an opportunity to explore why some species are protected from the detrimental aspects of high-fat-diet-induced dysfunction, and to translate these findings into benefits for human health.
摘要：
在人类和动物模型中，高饱和脂肪饮食与血管功能障碍和认知障碍有关.实验动物为更具侵入性的高脂肪饮食相关研究提供了极好的模型。然而,需要考虑人类和普通动物模型在代谢对高脂肪饮食的反应方面的生理差异。这里,我们回顾了可能影响动物模型机理研究可翻译性的因素，特别注意高脂饮食对血管结局的影响.我们提请注意代谢综合征和啮齿动物血脂异常之间的分离，与人类的状态不同，这两种情况经常发生。我们还讨论了物种之间对饮食中常量营养素的代谢和血管效应的脆弱性。动物研究的结果可以更好地解释为功能障碍的建模特定方面。我们得出的结论是，物种之间的差异为探索为什么某些物种受到保护免受高脂肪饮食引起的功能障碍的有害方面提供了机会。并将这些发现转化为对人类健康的益处。
