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Abstract：
Spermatogenesis is a complex and elaborate differentiation process and is vital for male fertility. Sertoli cells play a major role in fertility and induce spermatogenesis by protecting, nourishing, and supporting germ cells. It has been speculated that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) could directly affect the male reproductive system, and therefore heredity and fertility. The similarity of SARS-CoV-2 to SARS-CoV could confirm this hypothesis because both viruses use angiotensin-converting enzyme (ACE2) as the receptor to enter human cells. ACE2 is expressed by Sertoli cells and other testicular cells, therefore COVID-19 has the potential to impair fertility by destroying Sertoli cells. This hypothesis should be evaluated and confirmed by monitoring fertility in patients with COVID-19.
摘要：
精子发生是一个复杂而复杂的分化过程，对男性生育能力至关重要。支持细胞在生育力中起主要作用，并通过保护，滋养，和支持生殖细胞。据推测，严重急性呼吸道综合症冠状病毒2（SARS-CoV-2）可直接影响男性生殖系统，因此遗传和生育能力。SARS-CoV-2与SARS-CoV的相似性可以证实这一假设，因为两种病毒都使用血管紧张素转换酶（ACE2）作为受体进入人细胞。ACE2由睾丸支持细胞和其他睾丸细胞表达，因此，COVID-19有可能通过破坏支持细胞来损害生育能力。应通过监测COVID-19患者的生育能力来评估和证实这一假设。
