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Abstract：
Electrical stimulation is regarded pivotal to promote repair of nerve injuries, however, failed to get extensive application in vivo due to the challenges in noninvasive electrical loading accompanying with construction of biomimetic cell niche. Herein, a new concept of magneto responsive electric 3D matrix for remote and wireless electrical stimulation is demonstrated. By the preparation of magnetoelectric core/shell structured Fe3 O4 @BaTiO3 NPs-loaded hyaluronan/collagen hydrogels, which recapitulate considerable magneto-electricity and vital features of native neural extracellular matrix, the enhancement of neurogenesis both in cellular level and spinal cord injury in vivo with external pulsed magnetic field applied is proved. The findings pave the way for a novel class of remote controlling and delivering electricity through extracellular niches-mimicked hydrogel network, arising prospects not only in neurogenesis but also in human-computer interaction with higher resolution.
摘要：
电刺激被认为是促进神经损伤修复的关键,然而,由于伴随着仿生细胞生态位构建的非侵入性电负载的挑战，未能在体内得到广泛的应用。在这里，演示了用于远程和无线电电刺激的磁响应电3D矩阵的新概念。通过制备磁电核/壳结构的Fe3O4@BaTiO3NPs负载的透明质酸/胶原蛋白水凝胶，概括了相当大的磁电和天然神经细胞外基质的重要特征，证明了外加脉冲磁场可增强细胞水平和体内脊髓损伤的神经发生。这些发现为一类新型的远程控制和通过细胞外生态位模拟的水凝胶网络输送电力铺平了道路。不仅在神经发生方面，而且在具有更高分辨率的人机交互方面也有前景。
