PDF(Sci-hub)
Abstract：
Olive oil and components might have a beneficial effect on Metabolic Syndrome (MetS). The aim of this review and meta-analysis was to assess whether those effects are related to hydroxytyrosol or oleic acid contents, or the combination of them as olive oil, and how powerful is this effect.
A systematic literature search was performed in MEDLINE via Pubmed, Web of Science (WOS) core collection, and Virtual Health Library (VHL) via LILACS and IBECS (Spain). MeSH terms used were \"obesity\", \"body weight\", \"body mass index\", \"adipose tissue\", \"lipid metabolism\", \"LDL\", \"HDL\", \"VLDL\", \"insulin resistance\", \"glucose\", \"insulin\", \"hypertension\", \"arterial pressure\", \"olive oil\", \"oleic acid\", and other (non-MeSH) terms: \"total antioxidant capacity\", \"total antioxidant status\", \"hydroxytyrosol\" (PROSPERO ID: CRD42021247614). Results of the included studies were meta-analyzed with the RevMan 5.3 program, assuming a random effects model.
76 articles (67 different trials) were identified. Hydroxytyrosol had no effect on MetS [combined standardized mean differences (SMD) = 0.01 (CI 95%: [-0.23, 0.25], I2 = 83%; p = 0.920)]. Oleic acid had no significant beneficial effect on MetS [SMD = 0.03 (CI 95%: [-0.01, 0.07], I2 = 0%); p = 0.150], but it improved lipid profile [SMD = 0.06 (CI 95%: [-0.00, 0.12], I2 = 0%); p = 0. 050]. Olive oil had no effect on MetS [SMD = -0.01 (CI 95%: [-0.05, 0.03]), I2 = 55%; p = 0.550)]. The supplementation with hydroxytyrosol, oleic acid or olive oil showed a beneficial effect on antioxidant capacity related to components of MetS [SMD = 0.31 (CI 95%: [-0.34, 0.95], I2 = 81%)]; p = 0.35).
Most articles compared olive oil and oleic acid with other strategies specially designed for MetS management. Our findings suggest that olive oil or oleic acid consumption are as good as the other strategies to manage MetS.
A systematic literature search was performed in MEDLINE via Pubmed, Web of Science (WOS) core collection, and Virtual Health Library (VHL) via LILACS and IBECS (Spain). MeSH terms used were \"obesity\", \"body weight\", \"body mass index\", \"adipose tissue\", \"lipid metabolism\", \"LDL\", \"HDL\", \"VLDL\", \"insulin resistance\", \"glucose\", \"insulin\", \"hypertension\", \"arterial pressure\", \"olive oil\", \"oleic acid\", and other (non-MeSH) terms: \"total antioxidant capacity\", \"total antioxidant status\", \"hydroxytyrosol\" (PROSPERO ID: CRD42021247614). Results of the included studies were meta-analyzed with the RevMan 5.3 program, assuming a random effects model.
76 articles (67 different trials) were identified. Hydroxytyrosol had no effect on MetS [combined standardized mean differences (SMD) = 0.01 (CI 95%: [-0.23, 0.25], I2 = 83%; p = 0.920)]. Oleic acid had no significant beneficial effect on MetS [SMD = 0.03 (CI 95%: [-0.01, 0.07], I2 = 0%); p = 0.150], but it improved lipid profile [SMD = 0.06 (CI 95%: [-0.00, 0.12], I2 = 0%); p = 0. 050]. Olive oil had no effect on MetS [SMD = -0.01 (CI 95%: [-0.05, 0.03]), I2 = 55%; p = 0.550)]. The supplementation with hydroxytyrosol, oleic acid or olive oil showed a beneficial effect on antioxidant capacity related to components of MetS [SMD = 0.31 (CI 95%: [-0.34, 0.95], I2 = 81%)]; p = 0.35).
Most articles compared olive oil and oleic acid with other strategies specially designed for MetS management. Our findings suggest that olive oil or oleic acid consumption are as good as the other strategies to manage MetS.
摘要：
橄榄油和成分可能对代谢综合征（MetS）有有益的影响。这篇综述和荟萃分析的目的是评估这些影响是否与羟基酪醇或油酸含量有关，或者它们的组合作为橄榄油，以及这种效果有多强大。
通过Pubmed在MEDLINE中进行了系统的文献检索，WebofScience(WOS)核心集合,和虚拟健康图书馆(VHL)通过LILACS和IBECS(西班牙)。使用的MeSH术语是“肥胖”，“体重”，“体重指数”，“脂肪组织”，“脂质代谢”，\"LDL\",\"HDL\",\"VLDL\",“胰岛素抵抗”，“葡萄糖”，“胰岛素”，“高血压”，“动脉压”，\"橄榄油\",“油酸”，和其他(非MeSH)术语：“总抗氧化能力”，“总抗氧化剂状态”，\"羟基酪醇\"(PROSPEROID:CRD42021247614)。纳入研究的结果采用RevMan5.3程序进行荟萃分析，假设随机效应模型。
确定了76篇文章（67项不同的试验）。羟基酪醇对MetS没有影响[综合标准化平均差（SMD）=0.01（CI95％：[-0.23，0.25]，I2=83%；p=0.920)]。油酸对MetS没有显著的有益作用[SMD=0.03(CI95%:[-0.01,0.07],I2=0%)；p=0.150]，但它改善了血脂状况[SMD=0.06（CI95%：[-0.00，0.12]，I2=0%)；p=0。050].橄榄油对代谢综合征无影响[SMD=-0.01（CI95%：[-0.05，0.03]），I2=55%；p=0.550)]。补充羟基酪醇，油酸或橄榄油对与MetS成分相关的抗氧化能力显示出有益的作用[SMD=0.31(CI95%:[-0.34,0.95],I2=81%)]；p=0.35)。
大多数文章将橄榄油和油酸与其他专门为MetS管理设计的策略进行了比较。我们的研究结果表明，橄榄油或油酸的消费与其他管理MetS的策略一样好。
通过Pubmed在MEDLINE中进行了系统的文献检索，WebofScience(WOS)核心集合,和虚拟健康图书馆(VHL)通过LILACS和IBECS(西班牙)。使用的MeSH术语是“肥胖”，“体重”，“体重指数”，“脂肪组织”，“脂质代谢”，\"LDL\",\"HDL\",\"VLDL\",“胰岛素抵抗”，“葡萄糖”，“胰岛素”，“高血压”，“动脉压”，\"橄榄油\",“油酸”，和其他(非MeSH)术语：“总抗氧化能力”，“总抗氧化剂状态”，\"羟基酪醇\"(PROSPEROID:CRD42021247614)。纳入研究的结果采用RevMan5.3程序进行荟萃分析，假设随机效应模型。
确定了76篇文章（67项不同的试验）。羟基酪醇对MetS没有影响[综合标准化平均差（SMD）=0.01（CI95％：[-0.23，0.25]，I2=83%；p=0.920)]。油酸对MetS没有显著的有益作用[SMD=0.03(CI95%:[-0.01,0.07],I2=0%)；p=0.150]，但它改善了血脂状况[SMD=0.06（CI95%：[-0.00，0.12]，I2=0%)；p=0。050].橄榄油对代谢综合征无影响[SMD=-0.01（CI95%：[-0.05，0.03]），I2=55%；p=0.550)]。补充羟基酪醇，油酸或橄榄油对与MetS成分相关的抗氧化能力显示出有益的作用[SMD=0.31(CI95%:[-0.34,0.95],I2=81%)]；p=0.35)。
大多数文章将橄榄油和油酸与其他专门为MetS管理设计的策略进行了比较。我们的研究结果表明，橄榄油或油酸的消费与其他管理MetS的策略一样好。
