Abstract：
Chronic pruritus carries a significant burden of disease and is associated with a negative impact on quality of life. African Americans are disproportionately burdened by chronic pruritic disorders, including but not limited to atopic dermatitis, prurigo nodularis, inflammatory scalp dermatoses, pathologic scarring, and HIV-related dermatoses. Racial differences in skin structure and function may contribute to the pathogenesis of itch in African Americans. Itch perception and response to treatment in African Americans remain understudied and not well understood. As such, there is a large unmet need with regard to the knowledge and management of pruritus in African Americans. This review highlights notable differences in the epidemiology, pathophysiology, genetic predisposition, clinical presentation, and response to treatment for select pruritic skin conditions. By addressing itch as an unmet need in African Americans, we hope to improve patient outcomes and lessen disparities in dermatologic care.
摘要：
慢性瘙痒具有显著的疾病负担,并且与对生活质量的负面影响相关。非洲裔美国人受慢性瘙痒疾病的负担不成比例，包括但不限于特应性皮炎，结节性痒疹,炎症性头皮皮肤病，病理性瘢痕,和艾滋病毒相关的皮肤病。皮肤结构和功能的种族差异可能导致非裔美国人瘙痒的发病机理。非洲裔美国人对瘙痒的感知和对治疗的反应仍然缺乏研究，也没有得到很好的理解。因此，关于非洲裔美国人瘙痒的知识和管理，存在大量未满足的需求。这篇综述强调了流行病学上的显著差异，病理生理学,遗传易感性,临床表现,以及对选择瘙痒皮肤状况的治疗反应。通过将瘙痒视为非裔美国人的未满足需求，我们希望改善患者的治疗效果，减少皮肤病学护理方面的差异。
