Abstract:
Introduction: Many patients sensitized to mites remain symptomatic and uncontrolled despite traditional treatment. Sublingual immunotherapy (SLIT) has demonstrated to reduce the symptoms of allergic rhinitis, the need for additional drug treatments, and to reduce the number of moderate and severe exacerbations in patients with allergic asthma caused by mites that had not been adequately controlled.Areas covered: After reviewing the most recent literature, a scientific committee composed by five pneumologists experts in asthma proposed 41 items that addressed the diagnosis of allergic asthma caused by mites, the role of house dust mite (HDM) SLIT tablet in the therapeutic plan and in the control of the disease, and the profile of patients with asthma candidates for this therapy. Through a modified Delphi method, the items were send to 106 pneumologists involved in asthma to be agreed.Expert opinion: The high degree of consensus reached by the panel of pneumologists shows the importance of HDM SLIT tablet in the treatment of allergic asthma caused by mites, particularly taking into account that they barely use this therapy because until now they did not have a registered treatment with solid evidence of efficacy and safety.
摘要:
简介:尽管传统治疗,许多对螨虫敏感的患者仍有症状且不受控制。舌下免疫疗法(SLIT)已被证明可以减轻过敏性鼻炎的症状,需要额外的药物治疗,并减少未得到充分控制的螨虫引起的过敏性哮喘患者的中度和重度加重次数。涵盖的领域:在回顾了最新的文献之后,由五名哮喘肺炎专家组成的科学委员会提出了41个项目,涉及螨虫引起的过敏性哮喘的诊断,屋尘螨(HDM)SLIT片剂在治疗计划和疾病控制中的作用,以及这种疗法的哮喘患者的情况。通过改进的德尔菲法,这些项目被发送给106名哮喘相关的肺炎专家,以达成一致。专家观点:肺炎专家小组达成的高度共识表明,HDMSLIT片在治疗螨虫引起的过敏性哮喘中的重要性,特别是考虑到他们几乎不使用这种疗法,因为直到现在他们还没有获得有效和安全性证据的注册治疗。