Abstract：
The aim of the systematic review was to analyze the use of combination of bone substitutes and vectors in periodontology and implantology among animals models and humans. Electronic databases were searched, and additional hand search was performed. The research strategy was achieved according to the PRISMA guidelines. The including criteria were: combination of bone substitutes and vectors, in vivo studies, a precise number of specimens, histological and radiographic analysis, written in English. The risk of bias was evaluated for individual studies. Thirty-two articles were selected and investigated in this systematic review. The results do not show a superiority of the use of composite biomaterial in comparison with simple biomaterial but suggest the efficacity of their utilization as a carrier of bioactive agents. Future studies need to identify the suitable association of bone substitutes and vectors and explore interest in their use such as the support of growth factors.
摘要：
系统综述的目的是分析动物模型和人类在牙周学和种植学中结合使用骨替代物和载体。搜索了电子数据库，并进行了额外的手工搜索。研究策略是根据PRISMA指南实现的。包括的标准是：骨替代物和载体的组合，体内研究,精确数量的标本，组织学和影像学分析，用英语写的。对个别研究的偏倚风险进行评估。本系统综述选择并调查了32篇文章。与简单的生物材料相比，结果并未显示出使用复合生物材料的优越性，但表明了将其用作生物活性剂载体的有效性。未来的研究需要确定骨替代物和载体的合适关联，并探索对其使用的兴趣，例如生长因子的支持。
