关键词: Filamentous fungi antifungal treatment emerging pathogens invasive fungal disease

来  源:   DOI:10.1080/1040841X.2021.1927978   PDF(Sci-hub)

Abstract:
Fungal infections have increased in recent years due to host factors, such as oncohaematological and transplant-related disorders, immunosuppressive therapy, and AIDS. Additionally, molecular and proteomic facilities have become available to identify previously unrecognizable opportunists. For these reasons, reports on less-known and recalcitrant mycoses, such as those caused by black fungi, hyaline filamentous fungi, coelomycetes, Mucorales, and non-Candida yeasts have emerged. In this review, novel taxonomy in these groups, which often are multi-resistant to one or several classes of antifungals, is discussed. Clinical presentations, diagnosis and current treatment of some major groups are summarised.
摘要:
由于宿主因素,真菌感染近年来有所增加,如肿瘤血液学和移植相关疾病,免疫抑制治疗,和艾滋病。此外,分子和蛋白质组学设施已成为可用来识别以前无法识别的机会主义者。由于这些原因,关于鲜为人知和顽固性真菌病的报道,比如那些由黑色真菌引起的,透明丝状真菌,腔孢子菌,Mucorales,和非念珠菌酵母已经出现。在这次审查中,这些群体中的新分类法,通常对一类或几类抗真菌药具有多重抗性,正在讨论。临床表现,总结了一些主要人群的诊断和当前治疗。
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