%0 Journal Article %T Recent developments in less known and multi-resistant fungal opportunists. %A Vitale RG %A Giudicessi SL %A Romero SM %A Al-Hatmi AMS %A Li Q %A de Hoog GS %J Crit Rev Microbiol %V 47 %N 6 %D Nov 2021 %M 34096817 %F 7.391 %R 10.1080/1040841X.2021.1927978 %X Fungal infections have increased in recent years due to host factors, such as oncohaematological and transplant-related disorders, immunosuppressive therapy, and AIDS. Additionally, molecular and proteomic facilities have become available to identify previously unrecognizable opportunists. For these reasons, reports on less-known and recalcitrant mycoses, such as those caused by black fungi, hyaline filamentous fungi, coelomycetes, Mucorales, and non-Candida yeasts have emerged. In this review, novel taxonomy in these groups, which often are multi-resistant to one or several classes of antifungals, is discussed. Clinical presentations, diagnosis and current treatment of some major groups are summarised.