PDF(Pubmed)
Abstract：
UNASSIGNED: Hyperosmolar therapy is a well-established method to approach brain relaxation during craniotomy. Mannitol is used with a wide range of dosing regimens, combination with loop diuretics exerts a synergistic effect resulting in both reduction of the dose and its complications. Ultrasound measurement of optic nerve sheath diameter (ONSD) gives reliable information about intracranial pressure (ICP) and avoids overdosing and complications of osmotherapy.
UNASSIGNED: In this study, we compare the ordinary dose of mannitol with the low dose combined with furosemide and detect the effect on ICP by ONSD.
UNASSIGNED: This is a prospective, randomized, double-blind study involving 60 patients undergoing supratentorial brain tumor surgery.
UNASSIGNED: Sixty patients were enrolled in this study, divided into two equal groups: Group M received mannitol 1 g.kg-1: while Group F received mannitol 0.25 g.kg-1 and furosemide 0.5 mg.kg-1. Reduction in ONSD measurement was the primary objective, while brain-relaxation score (BRS), hemodynamic changes, urine output, serum lactate, and changes in serum electrolyte were the secondary objectives.
UNASSIGNED: Data collected were analyzed using SPSS software, IBM, USA, version 22. P value was considered significant if <0.05.
UNASSIGNED: ONSD and BRS showed no statistically significant difference between the studied groups. After diuresis, Group M showed significant reduction in heart rate and mean arterial blood pressure, serum sodium, potassium, and lactate (P = 0.02, P = 0.02, P = 0.001, P = 0.001, P = 0.001, P = 0.001 respectively), with increased urine output (UOP) and fluids replacement (P = 0.00, P = 0.01, respectively).
UNASSIGNED: Compared to high dose, adding loop diuretics to low-dose mannitol during supratentorial brain tumor surgeries resulted in comparable BRSs with a lower incidence of hemodynamic and metabolic disturbances.
UNASSIGNED: In this study, we compare the ordinary dose of mannitol with the low dose combined with furosemide and detect the effect on ICP by ONSD.
UNASSIGNED: This is a prospective, randomized, double-blind study involving 60 patients undergoing supratentorial brain tumor surgery.
UNASSIGNED: Sixty patients were enrolled in this study, divided into two equal groups: Group M received mannitol 1 g.kg-1: while Group F received mannitol 0.25 g.kg-1 and furosemide 0.5 mg.kg-1. Reduction in ONSD measurement was the primary objective, while brain-relaxation score (BRS), hemodynamic changes, urine output, serum lactate, and changes in serum electrolyte were the secondary objectives.
UNASSIGNED: Data collected were analyzed using SPSS software, IBM, USA, version 22. P value was considered significant if <0.05.
UNASSIGNED: ONSD and BRS showed no statistically significant difference between the studied groups. After diuresis, Group M showed significant reduction in heart rate and mean arterial blood pressure, serum sodium, potassium, and lactate (P = 0.02, P = 0.02, P = 0.001, P = 0.001, P = 0.001, P = 0.001 respectively), with increased urine output (UOP) and fluids replacement (P = 0.00, P = 0.01, respectively).
UNASSIGNED: Compared to high dose, adding loop diuretics to low-dose mannitol during supratentorial brain tumor surgeries resulted in comparable BRSs with a lower incidence of hemodynamic and metabolic disturbances.
摘要：
■高渗性治疗是在开颅手术期间进行脑松弛的一种公认的方法。甘露醇与多种给药方案一起使用，与loop利尿剂的组合发挥协同作用，导致剂量减少及其并发症。视神经鞘直径（ONSD）的超声测量提供了有关颅内压（ICP）的可靠信息，并避免了过度给药和渗透治疗的并发症。
■在这项研究中，我们比较了普通剂量的甘露醇与低剂量的呋塞米联合使用，并通过ONSD检测了对ICP的影响。
■这是一个前景，随机化，双盲研究涉及60例接受幕上脑肿瘤手术的患者。
■本研究纳入了60例患者，分为两组：M组接受甘露醇1g.kg-1：而F组接受甘露醇0.25g.kg-1和呋塞米0.5mg。kg-1.减少ONSD测量是主要目标，而大脑放松评分（BRS），血液动力学变化,尿量,血清乳酸，血清电解质的变化是次要目标。
■使用SPSS软件分析收集的数据，IBM,美国,版本22.如果<0.05,则P值被认为是显著的。
■ONSD和BRS在研究组之间没有统计学上的显着差异。利尿后,M组心率和平均动脉血压显著降低,血清钠，钾，和乳酸（分别为P=0.02，P=0.02，P=0.001，P=0.001，P=0.001，P=0.001），尿量增加（UOP）和补液（分别为P=0.00，P=0.01）。
■与高剂量相比，在幕上脑肿瘤手术期间,在低剂量甘露醇中加入环状利尿剂可产生相当的BRS,血液动力学和代谢紊乱的发生率较低.
■在这项研究中，我们比较了普通剂量的甘露醇与低剂量的呋塞米联合使用，并通过ONSD检测了对ICP的影响。
■这是一个前景，随机化，双盲研究涉及60例接受幕上脑肿瘤手术的患者。
■本研究纳入了60例患者，分为两组：M组接受甘露醇1g.kg-1：而F组接受甘露醇0.25g.kg-1和呋塞米0.5mg。kg-1.减少ONSD测量是主要目标，而大脑放松评分（BRS），血液动力学变化,尿量,血清乳酸，血清电解质的变化是次要目标。
■使用SPSS软件分析收集的数据，IBM,美国,版本22.如果<0.05,则P值被认为是显著的。
■ONSD和BRS在研究组之间没有统计学上的显着差异。利尿后,M组心率和平均动脉血压显著降低,血清钠，钾，和乳酸（分别为P=0.02，P=0.02，P=0.001，P=0.001，P=0.001，P=0.001），尿量增加（UOP）和补液（分别为P=0.00，P=0.01）。
■与高剂量相比，在幕上脑肿瘤手术期间,在低剂量甘露醇中加入环状利尿剂可产生相当的BRS,血液动力学和代谢紊乱的发生率较低.
