UNASSIGNED: In this study, we compare the ordinary dose of mannitol with the low dose combined with furosemide and detect the effect on ICP by ONSD.
UNASSIGNED: This is a prospective, randomized, double-blind study involving 60 patients undergoing supratentorial brain tumor surgery.
UNASSIGNED: Sixty patients were enrolled in this study, divided into two equal groups: Group M received mannitol 1 g.kg-1: while Group F received mannitol 0.25 g.kg-1 and furosemide 0.5 mg.kg-1. Reduction in ONSD measurement was the primary objective, while brain-relaxation score (BRS), hemodynamic changes, urine output, serum lactate, and changes in serum electrolyte were the secondary objectives.
UNASSIGNED: Data collected were analyzed using SPSS software, IBM, USA, version 22. P value was considered significant if <0.05.
UNASSIGNED: ONSD and BRS showed no statistically significant difference between the studied groups. After diuresis, Group M showed significant reduction in heart rate and mean arterial blood pressure, serum sodium, potassium, and lactate (P = 0.02, P = 0.02, P = 0.001, P = 0.001, P = 0.001, P = 0.001 respectively), with increased urine output (UOP) and fluids replacement (P = 0.00, P = 0.01, respectively).
UNASSIGNED: Compared to high dose, adding loop diuretics to low-dose mannitol during supratentorial brain tumor surgeries resulted in comparable BRSs with a lower incidence of hemodynamic and metabolic disturbances.
■在这项研究中,我们比较了普通剂量的甘露醇与低剂量的呋塞米联合使用,并通过ONSD检测了对ICP的影响。
■这是一个前景,随机化,双盲研究涉及60例接受幕上脑肿瘤手术的患者。
■本研究纳入了60例患者,分为两组:M组接受甘露醇1g.kg-1:而F组接受甘露醇0.25g.kg-1和呋塞米0.5mg。kg-1.减少ONSD测量是主要目标,而大脑放松评分(BRS),血液动力学变化,尿量,血清乳酸,血清电解质的变化是次要目标。
■使用SPSS软件分析收集的数据,IBM,美国,版本22.如果<0.05,则P值被认为是显著的。
■ONSD和BRS在研究组之间没有统计学上的显着差异。利尿后,M组心率和平均动脉血压显著降低,血清钠,钾,和乳酸(分别为P=0.02,P=0.02,P=0.001,P=0.001,P=0.001,P=0.001),尿量增加(UOP)和补液(分别为P=0.00,P=0.01)。
■与高剂量相比,在幕上脑肿瘤手术期间,在低剂量甘露醇中加入环状利尿剂可产生相当的BRS,血液动力学和代谢紊乱的发生率较低.