Abstract：
Patients diagnosed with cancer are often plagued with debilitating side effects post-chemotherapy treatment. One such side effect is chemotherapy-induced cognitive impairment or \'chemobrain\'. Rodent models are commonly used to investigate pathogenesis and potential therapeutic strategies. However, concerns have been raised regarding inadequacies in reporting of animal studies rendering them unreliable and irreproducible. The aim of this systematic review was to assess compliance with the ARRIVE reporting guidelines in peer-reviewed publications evaluating chemotherapy-induced cognitive changes in rodent models, and to determine if the introduction of the ARRIVE guidelines has improved quality of reporting. A comprehensive search was conducted to identify relevant peer-reviewed publications. Ninety-seven studies met the eligibility criteria, and publication compliance with the ARRIVE guideline reporting was assessed. No studies achieved full adherence with the ARRIVE guidelines. Furthermore, no significant improvement was demonstrated in the overall compliance score post-ARRIVE. Given the lack of standardisation of animal models in this research area, these results pose particular threat to future progress and translation of findings in this area of research. These results highlight the need for stricter adherence to the ARRIVE guidelines by journal editors and reviewers. Animal Ethics Committees also have an important educative role in improving knowledge and awareness of the guidelines amongst researchers.
摘要：
被诊断患有癌症的患者通常在化疗后受到使人衰弱的副作用的困扰。这种副作用之一是化疗引起的认知障碍或“化学疗法”。啮齿动物模型通常用于研究发病机理和潜在的治疗策略。然而,人们对动物研究报告中的不足提出了担忧，这些不足使它们不可靠和不可复制。本系统评价的目的是评估同行评审出版物中ARRIVE报告指南的依从性，评估啮齿动物模型中化疗引起的认知变化。并确定ARRIVE指南的引入是否提高了报告质量。进行了全面搜索，以确定相关的同行评审出版物。97项研究符合资格标准,并评估了出版物对ARRIVE指南报告的依从性.没有研究完全遵守ARRIVE指南。此外，ARRIVE后的总体依从性评分没有显著改善.鉴于该研究领域的动物模型缺乏标准化，这些结果对该研究领域的未来进展和结果的翻译构成了特别的威胁。这些结果强调了期刊编辑和审稿人更严格地遵守ARRIVE指南的必要性。动物伦理委员会在提高研究人员对指南的认识和认识方面也具有重要的教育作用。
